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. 2023 May;175(1):45-48.
doi: 10.1007/s10517-023-05808-z. Epub 2023 Jun 20.

The Role of P2Y6 Receptors in the Mechanisms of the Neuroprotective Effect of Citicoline

G Z Sufianova  1   2 , A G Shapkin  1   2 , M S Khlestkina  1   2 , L N Maslov  3 , A V Mukhomedzyanov  3 , N S Voronkov  3 , A A Sufianov  2   4
Affiliations

The Role of P2Y6 Receptors in the Mechanisms of the Neuroprotective Effect of Citicoline

G Z Sufianova et al. Bull Exp Biol Med. 2023 May.

Abstract

Spontaneous bioelectrical activity of the brain and the duration of gasping were recorded in mice during modeling of global strangulation ischemia of the brain against the background of preventive administration of citicoline. The maximum neuroprotective effect of citicoline was observed when it was administered 60 min before the simulation of ischemia and was completely prevented by preliminary administration of a selective P2Y6 receptor antagonist MRS2578. The obtained experimental data attest to the leading role of receptor mechanisms in the implementation of neuroprotective activity of citicoline.

Keywords: MRS2578; P2Y6 receptor; brain ischemia; citicoline; neuroprotection.

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References

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