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. 2023 Jun 20;329(23):2088-2089.
doi: 10.1001/jama.2023.7467.

Development of Duffy Null-Specific Absolute Neutrophil Count Reference Ranges

Lauren E Merz  1 , Miriam A Osei  1 , Charlotte M Story  1 , Revital Yefidoff Freedman  2 , Robin Smeland-Wagman  3 , Richard M Kaufman  3 , Maureen Okam Achebe  2
Affiliations

Development of Duffy Null-Specific Absolute Neutrophil Count Reference Ranges

Lauren E Merz et al. JAMA. .
No abstract available

Plain language summary

This study establishes a Duffy null phenotype–specific absolute neutrophil count reference range to optimize care and improve health equity.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Achebe reported receiving personal fees for being a member of scientific advisory boards for Pharmacosmos A/S, AMAG Pharmaceuticals, Global Blood Therapeutics, and Fulcrum Pharmaceuticals. No other disclosures were reported.

Figures

Figure.
Figure.. Duffy Null Absolute Neutrophil Count Reference Range Compared With Current Institutional Reference Range
One hundred twenty Duffy null samples are represented in the histogram. The central 95% reference range for the Duffy null cohort is 1210/μL to 5390/μL. The overlying bell curve represents the current institutional central 95% reference range of 1900/μL to 7600/μL. There is a significant different between the Duffy reference median and the current reference median (2820/μL vs 4750/μL; P < .001).
See this image and copyright information in PMC

References

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