. 2023 Sep;72(9):1642-1650.

doi: 10.1136/gutjnl-2023-329948. Epub 2023 Jun 20.

The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease

Loris Riccardo Lopetuso^#^{1

2

3}, Sara Deleu^#⁴, Lihi Godny⁵, Valentina Petito⁶, Pierluigi Puca^{6

7}, Federica Facciotti⁸, Harry Sokol⁹, Gianluca Ianiro^{7

10}, Luca Masucci¹¹, Maria Abreu¹², Iris Dotan⁵, Samuel Paul Costello¹³, Ailsa Hart¹⁴, Tariq H Iqbal¹⁵, Sudarshan Paramsothy¹⁶, Maurizio Sanguinetti¹¹, Silvio Danese¹⁷, Herbert Tilg¹⁸, Fabio Cominelli¹⁹, Theresa T Pizarro²⁰, Alessandro Armuzzi^{21

22}, Giovanni Cammarota^{7

10}, Antonio Gasbarrini^{6

7

10}, Séverine Vermeire^#⁴, Franco Scaldaferri^#^{6

7}

Affiliations

¹ IBD Unit, CEMAD Centro Malattie dell'Apparato Digerente, UOC di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy lopetusoloris@gmail.com.
² Department of Medicine and Ageing Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
³ Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
⁴ Department of Chronic Diseases & Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.
⁵ Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel.
⁶ IBD Unit, CEMAD Centro Malattie dell'Apparato Digerente, UOC di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
⁷ Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Roma, Italy.
⁸ Dipartimento di Biotecnologie e Bioscienze, University of Milan-Bicocca, Milano, Italy.
⁹ INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Gastroenterology Department, Sorbonne Universite, Paris, France.
¹⁰ UOC di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
¹¹ Department of Laboratory Sciences and Infectious Diseases, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
¹² Department of Medicine, Division of Gastroenterology, Crohn's and Colitis Center, University of Miami Miller School of Medicine, Miami, Florida, USA.
¹³ Department of Gastroenterology, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.
¹⁴ IBD Unit, Saint Mark's Hospital, Harrow, UK.
¹⁵ Microbiome Treatment Center, University of Birmingham, Birmingham, UK.
¹⁶ Gastroenterology and Liver Services, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.
¹⁷ Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and University Vita-Salute San Raffaele, Milano, Italy.
¹⁸ Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medizinische Universitat Innsbruck, Innsbruck, Austria.
¹⁹ Division of Gastroenterology and Liver Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
²⁰ Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
²¹ Deparment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy.
²² IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy.

^# Contributed equally.

PMID: 37339849
PMCID: PMC10423477
DOI: 10.1136/gutjnl-2023-329948

The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease

Loris Riccardo Lopetuso et al. Gut. 2023 Sep.

. 2023 Sep;72(9):1642-1650.

doi: 10.1136/gutjnl-2023-329948. Epub 2023 Jun 20.

Authors

Affiliations

¹ IBD Unit, CEMAD Centro Malattie dell'Apparato Digerente, UOC di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy lopetusoloris@gmail.com.
² Department of Medicine and Ageing Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
³ Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
⁴ Department of Chronic Diseases & Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.
⁵ Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel.
⁶ IBD Unit, CEMAD Centro Malattie dell'Apparato Digerente, UOC di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
⁷ Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Roma, Italy.
⁸ Dipartimento di Biotecnologie e Bioscienze, University of Milan-Bicocca, Milano, Italy.
⁹ INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Gastroenterology Department, Sorbonne Universite, Paris, France.
¹⁰ UOC di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
¹¹ Department of Laboratory Sciences and Infectious Diseases, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
¹² Department of Medicine, Division of Gastroenterology, Crohn's and Colitis Center, University of Miami Miller School of Medicine, Miami, Florida, USA.
¹³ Department of Gastroenterology, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.
¹⁴ IBD Unit, Saint Mark's Hospital, Harrow, UK.
¹⁵ Microbiome Treatment Center, University of Birmingham, Birmingham, UK.
¹⁶ Gastroenterology and Liver Services, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.
¹⁷ Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and University Vita-Salute San Raffaele, Milano, Italy.
¹⁸ Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medizinische Universitat Innsbruck, Innsbruck, Austria.
¹⁹ Division of Gastroenterology and Liver Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
²⁰ Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
²¹ Deparment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy.
²² IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy.

^# Contributed equally.

PMID: 37339849
PMCID: PMC10423477
DOI: 10.1136/gutjnl-2023-329948

Abstract

Background: Several randomised clinical trials (RCTs) performing faecal microbiota transplantation (FMT) for the management of inflammatory bowel disease (IBD), particularly for ulcerative colitis, have recently been published, but with major variations in study design. These include differences in administered dose, route and frequency of delivery, type of placebo and evaluated endpoints. Although the overall outcomes appear to be promising, they are highly dependent on both donor and recipient factors.

Objective: To develop concensus-based statements and recommendations for the evaluation, management and potential treatment of IBD using FMT in order to move towards standardised practices.

Design: An international panel of experts convened several times to generate evidence-based guidelines by performing a deep evaluation of currently available and/or published data. Twenty-five experts in IBD, immunology and microbiology collaborated in different working groups to provide statements on the following key issues related to FMT in IBD: (A) pathogenesis and rationale, (B) donor selection and biobanking, (C) FMT practices and (D) consideration of future studies and perspectives. Statements were evaluated and voted on by all members using an electronic Delphi process, culminating in a plenary consensus conference and generation of proposed guidelines.

Results and conclusions: Our group has provided specific statements and recommendations, based on best available evidence, with the end goal of providing guidance and general criteria required to promote FMT as a recognised strategy for the treatment of IBD.

Keywords: INFLAMMATORY BOWEL DISEASE; INTESTINAL MICROBIOLOGY; ULCERATIVE COLITIS.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

**Figure 1**
Faecal microbiota transplantation (FMT) pathway in IBD: from healthy donor to restored gut microbiota in patients with disease.

See this image and copyright information in PMC

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The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease

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The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease

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