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. 2023 Oct;82(1):42-46.
doi: 10.1007/s12020-023-03419-2. Epub 2023 Jun 20.

To support the use of NT-proBNP to better detect heart failure in patients with type 2 diabetes

Francesco Lapi  1 , Ettore Marconi  2 , Gerardo Medea  3 , Damiano Parretti  3 , Carlo Piccinni  4 , Aldo Pietro Maggioni  4   5 , Claudio Cricelli  3
Affiliations

To support the use of NT-proBNP to better detect heart failure in patients with type 2 diabetes

Francesco Lapi et al. Endocrine. 2023 Oct.

Abstract

Purpose: Heart failure (HF) is a chronic disease that causes approximately 300,000 and 250,000 deaths per year in Europe and United States, respectively. Type 2 Diabetes Mellitus (T2DM) is one the major risk factors of HF, and the investigation of NT-proBNP might support the early identification of HF in T2DM sufferers. Nevertheless, this parameter is poorly investigated. Thus, we aimed to demographically and clinically characterize diabetic patients which were prescribed with NT-proBNP in the primary care setting.

Methods: Using a primary care database, we formed a cohort of patients aged ≥18 years diagnosed with T2DM between 2002 and 2021. A multivariate Cox model was adopted to assess the determinants associated with the prescription of NT-proBNP.

Results: Among 167,961 T2DM patients, 7558 (4.5%, 95% CI: 4.4-4.6) were prescribed with NT-proBNP. Males and increasing age were expectedly associated with a higher propensity to be prescribed with NT-proBNP. In addition, a significant association was found for those suffering from obesity, ischemic cardiomyopathy, stroke, atrial fibrillation, hypertension, and with a Charlson Index of 2+.

Conclusion: These determinants might contribute to investigate the NT-proBNP in T2DM sufferers. A decision support system to appropriately ease the prescription of NT-proBNP might be therefore implemented in primary care settings.

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References

    1. A. Groenewegen, F.H. Rutten, A. Mosterd, A.W. Hoes, Epidemiology of heart failure. Eur. J. Heart Fail. 22, 1342–1356 (2020) - DOI - PubMed
    1. A. Ceriello, D. Catrinoiu, C. Chandramouli, F. Cosentino, A.C. Dombrowsky, B. Itzhak, N.M. Lalic, F. Prattichizzo, O. Schnell, P.M. Seferović, P. Valensi, E. Standl, CVD EASD Study Group, Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management. Cardiovasc. Diabetol. 20, 218 (2021).
    1. P.M. Seferović, M.C. Petrie, G.S. Filippatos, S.D. Anker, G. Rosano, J. Bauersachs, W.J. Paulus, M. Komajda, F. Cosentino, R.A. de Boer, D. Farmakis, W. Doehner, E. Lambrinou, Y. Lopatin, M.F. Piepoli, M.J. Theodorakis, H. Wiggers, J. Lekakis, A. Mebazaa, M.A. Mamas, C. Tschöpe, A.W. Hoes, J.P. Seferović, J. Logue, T. McDonagh, J.P. Riley, I. Milinković, M. Polovina, D.J. van Veldhuisen, M. Lainscak, A.P. Maggioni, F. Ruschitzka, J.J.V. McMurray, Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology. Eur. J. Heart Fail. 20, 853–872 (2018) - DOI - PubMed
    1. M. Kahn, A.D. Grayson, P.S. Chaggar, M.J. Ng Kam Chuen, A. Scott, C. Hughes, N.G. Campbell, Primary care heart failure service identifies a missed cohort of heart failure patients with reduced ejection fraction. Eur. Heart J. (2021). https://doi.org/10.1093/eurheartj/ehab629
    1. A. Maisel, C. Mueller, K. Adams, S.D. Anker, N. Aspromonte, J.G.F. Cleland, A. Cohen-Solal, U. Dahlstrom, A. DeMaria, S. Di Somma, G.S. Filippatos, G.C. Fonarow, P. Jourdain, M. Komajda, P.P. Liu, T. McDonagh, K. McDonald, A. Mebazaa, M.S. Nieminen, W.F. Peacock, M. Tubaro, R. Valle, M. Vanderhyden, C.W. Yancy, F. Zannad, E. Braunwald, State of the art: Using natriuretic peptide levels in clinical practice. Eur. J. Heart Fail. 10, 824–839 (2008) - DOI - PubMed

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