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. 2023 Jun 20;23(1):216.
doi: 10.1186/s12871-023-02182-1.

Associations of systemic oxygen consumption with age and body temperature under general anesthesia: retrospective cohort study

Satoshi Kimura  1 , Kazuyoshi Shimizu  2 , Hiroshi Morimatsu  2
Affiliations

Associations of systemic oxygen consumption with age and body temperature under general anesthesia: retrospective cohort study

Satoshi Kimura et al. BMC Anesthesiol. .

Retraction in

Abstract

Background: Body temperature (BT) is thought to have associations with oxygen consumption (VO2). However, there have been few studies in which the association between systemic VO2 and BT in humans was investigated in a wide range of BTs. The aims of this study were 1) to determine the association between VO2 and age and 2) to determine the association between VO2 and BT.

Methods: This study was a retrospective study of patients who underwent surgery under general anesthesia at a tertiary teaching hospital. VO2 was measured by the Dräger Perseus A500 anesthesia workstation (Dräger Medical, Lubeck, Germany). The associations of VO2 with age and BT were examined using spline regression and multivariable regression analysis with a random effect.

Results: A total of 7,567 cases were included in this study. A linear spline with one knot shows that VO2 was reduced by 2.1 ml/kg/min with one year of age (p < 0.001) among patients less than 18 years of age and that there was no significant change in VO2 among patients 18 years of age or older (estimate: 0.014 ml/kg/min, p = 0.08). VO2 in all bands of BT < 36.0 °C was not significantly different from VO2 in BT > = 36 °C and < 36.5 °C. Multivariable linear regression analysis showed that compared with VO2 in BT > = 36 °C and < 36.5 °C as a reference, VO2 levels were significantly higher by 0.57 ml/kg/min in BT > = 36.5 °C and < 37 °C (p < 0.001), by 1.8 ml/kg/min in BT > = 37 °C and < 37.5 °C (p < 0.001), by 3.6 ml/kg/min in BT > = 37.5 °C and < 38 °C (p < 0.001), by 4.9 ml/kg/min in BT > = 38 °C and < 38.5 °C (p < 0.001), and by 5.7 ml/kg/min in BT > = 38.5 °C (p < 0.001). The associations between VO2 and BT were significantly different among categorized age groups (p = 0.03).

Conclusions: VO2 increases in parallel with increase in body temperature in a hyperthermic state but remains constant in a hypothermic state. Neonates and infants, who have high VO2, may have a large systemic organ response in VO2 to change in BT.

Keywords: Body Temperature; General Anesthesia; Oxygen Consumption.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart
Fig. 2
Fig. 2
Association between oxygen consumption and age with body temperature between 36 °C and 36.5 °C. Cubic spline (left) and linear spline with one knot at the age of 18 years (right) were drawn on the scatter plot of VO2 and age. Abbreviations: VO2, oxygen consumption
Fig. 3
Fig. 3
Association between oxygen consumption and body temperature. Abbreviations: VO2, oxygen consumption; Ref, reference; *, p < 0.05; **, p < 0.01; *** p < 0.001
See this image and copyright information in PMC

References

    1. Friedman G, De Backer D, Shahla M, Vincent JL. Oxygen supply dependency can characterize septic shock. Intensive Care Med. 1998;24(2):118–123. doi: 10.1007/s001340050531. - DOI - PubMed
    1. Goonasekera CDA, Carcillo JA, Deep A. Oxygen delivery and oxygen consumption in pediatric fluid refractory septic shock during the first 42 h of therapy and their relationship to 28-day outcome. Front Pediatr. 2018;6:314. doi: 10.3389/fped.2018.00314. - DOI - PMC - PubMed
    1. Rossi AF, Seiden HS, Gross RP, Griepp RB. Oxygen transport in critically ill infants after congenital heart operations. Ann Thorac Surg. 1999;67(3):739–744. doi: 10.1016/S0003-4975(98)01255-7. - DOI - PubMed
    1. Hypothermia after Cardiac Arrest Study G: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346(8):549–556. - PubMed
    1. Polderman KH. Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med. 2009;37(7 Suppl):S186–202. doi: 10.1097/CCM.0b013e3181aa5241. - DOI - PubMed

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