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Review
. 2023 Sep;114(9):e23556.
doi: 10.1002/bip.23556. Epub 2023 Jun 21.

Beyond traditional therapy: Mucoadhesive polymers as a new frontier in oral cancer management

Subhayan Das  1 , Koushik Bhattacharya  2 , Jonny J Blaker  3   4 , Nikhil K Singha  2 , Mahitosh Mandal  1
Affiliations
Review

Beyond traditional therapy: Mucoadhesive polymers as a new frontier in oral cancer management

Subhayan Das et al. Biopolymers. 2023 Sep.

Abstract

In recent times mucoadhesive drug delivery systems are gaining popularity in oral cancer. It is a malignancy with high global prevalence. Despite significant advances in cancer therapeutics, improving the prognosis of late-stage oral cancer remains challenging. Targeted therapy using mucoadhesive polymers can improve oral cancer patients' overall outcome by offering enhanced oral mucosa bioavailability, better drug distribution and tissue targeting, and minimizing systemic side effects. Mucoadhesive polymers can also be delivered via different formulations such as tablets, films, patches, gels, and nanoparticles. These polymers can deliver an array of medicines, making them an adaptable drug delivery approach. Drug delivery techniques based on these mucoadhesive polymers are gaining traction and have immense potential as a prospective treatment for late-stage oral cancer. This review examines leading research in mucoadhesive polymers and discusses their potential applications in treating oral cancer.

Keywords: biomaterials; drug delivery; mucoadhesive polymers; oral cancer.

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References

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