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. 2023 Jul;67(4):387-395.
doi: 10.1007/s10384-023-01003-9. Epub 2023 Jun 21.

Validation of the postnatal growth and retinopathy of prematurity (G-ROP) screening criteria in a Thai cohort

Adisak Trinavarat  1 , Natthapicha Najmuangchan  2 , Sopapan Ngerncham  2 , Saranporn Piampradad  1 , Poonyawee Nunthanid  1 , Dussadee Tatritorn  1 , Thipsukon Amnartpanich  1 , Nutchanok Limkongngam  1 , Thanyaporn Praikanarat  1 , Niracha Arjkongharn  1 , Suthipol Udompunthurak  3 , La-Ongsri Atchaneeyasakul  4
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Validation of the postnatal growth and retinopathy of prematurity (G-ROP) screening criteria in a Thai cohort

Adisak Trinavarat et al. Jpn J Ophthalmol. 2023 Jul.

Abstract

Purpose: To validate Postnatal Growth and Retinopathy of Prematurity (G-ROP) criteria for Thai infants.

Study design: A retrospective review of infants receiving ROP screening during 2009-2020.

Methods: Baseline characteristics, clinical progression and final ROP outcomes were collected. G-ROP was applied to infants who met at least one of the following 6 criteria: birth weight (BW) below 1051 g, gestational age (GA) under 28 weeks, weight gain (WG) less than 120 g during postnatal day 10-19, WG less than 180 g during day 20-29, WG less than 170 g during day 30-39 and hydrocephalus.

Results: A total of 684 infants (boys, 53.4%) were included. Median (IQR) BW was 1200 (960-1470) grams and median GA was 30 (28-32) weeks. Prevalence of ROP was 26.6%, with 28 (4.1%) having type 1, 19 (2.8%) type 2 and, 135 (19.7%) having other ROP. Treatment was performed in 26 infants (3.8%). Sensitivity of G-ROP to include type 1, 2 or treatment-requiring ROP cases was 100% with 36.9% specificity, excluding 235 (34.4%) cases of unnecessary screening. To adjust for our setting of initial eye examination at 4 weeks' postnatal date, the last 2 criteria of G-ROP were replaced by the occurrence of grade 3 or 4 intraventricular hemorrhage (IVH). This modified G-ROP criteria yielded 100% sensitivity, 42.5% specificity and excluded 271 (39.6%) cases of unnecessary screening.

Conclusion: G-ROP criteria can be applied to our hospital setting. Occurrence of IVH grade 3 or 4 was proposed as an alternative in modified G-ROP criteria.

Keywords: Birth weight; Gestational age; Intraventricular hemorrhage; Postnatal weight gain; Retinopathy of prematurity.

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