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. 2023 Aug;40(8):768-774.
doi: 10.1111/echo.15639. Epub 2023 Jun 21.

Assessing the impact of transcatheter aortic valve replacement on myocardial work indices and left ventricular diastolic function in aortic valve stenosis patients

Danilo Franco  1   2 , Alessandro Santoro  1 , Giuseppe Di Gioia  1 , Marco Ferrone  1 , Stefania Tramonte  1 , Luigi Salemme  1 , Angelo Cioppa  1 , Gregory Popusoi  1 , Armando Pucciarelli  1 , Sebastiano Verdoliva  1 , Michele Franzese  1 , Simion Marga  3 , Dimitris Christodoulakis  1 , Emanuele Barbato  4 , Tullio Tesorio  1
Affiliations

Assessing the impact of transcatheter aortic valve replacement on myocardial work indices and left ventricular diastolic function in aortic valve stenosis patients

Danilo Franco et al. Echocardiography. 2023 Aug.

Abstract

Background: Aortic valve stenosis (AS) is the most common valvular heart disease worldwide. When timely intervention is performed, aortic valve replacement can improve patients' quality and duration of life. Load-independent left ventricular (LV) functional assessments, such as myocardial work indices (MWIs) and LV diastolic function parameters, could help clinicians decide on the optimal timing of intervention.

Aims: To evaluate the reliability of MWI in AS patients and the changes in MWI and LV diastolic function after transcatheter aortic valve replacement (TAVR).

Methods: We enrolled 53 consecutive patients with severe AS undergoing TAVR admitted between March 2021 and November 2021. MWIs and LV diastolic function were assessed before and after TAVR for each patient.

Results: All MWIs and LV diastolic function indices improved after TAVR. The degree of MWIs improvement was higher in patients with lower prior-TAVR MWI values, while the more severe the impairment of diastolic function, the greater the post-TAVR benefit.

Conclusion: The introduction of myocardial work parameters into the routine assessment of patients with AS could improve our understanding of cardiac performance and aid in identifying the optimal timing for surgical or percutaneous treatment.

Keywords: TAVR; aortic stenosis; diastolic disfunction; myocardial work index.

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References

REFERENCES

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