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Review
. 2023 Jun 6:13:1169500.
doi: 10.3389/fcimb.2023.1169500. eCollection 2023.

Regulation of gut microbiota: a novel pretreatment for complications in patients who have undergone kidney transplantation

Jiajia Ye  1 , Junxia Yao  2 , Fangfang He  1 , Jing Sun  1 , Zheng Zhao  1 , Yumei Wang  1
Affiliations
Review

Regulation of gut microbiota: a novel pretreatment for complications in patients who have undergone kidney transplantation

Jiajia Ye et al. Front Cell Infect Microbiol. .

Abstract

Kidney transplantation is an effective method to improve the condition of patients with end-stage renal disease. The gut microbiota significantly affects the immune system and can be used as an influencing factor to change the prognoses of patients who have undergone kidney transplantation. Recipients after kidney transplantation showed a lower abundance of Firmicutes and Faecalibacterium prausnitzii and a higher proportion of Bacteroidetes and Proteobacteria. After using prebiotics, synbiotics, and fecal microbiota transplantation to regulate the microbial community, the prognoses of patients who underwent kidney transplantation evidently improved. We aimed to determine the relationship between gut microbiota and various postoperative complications inpatients who have undergone kidney transplantation in recent years and to explore how gut microecology affects post-transplant complications. An in-depth understanding of the specific functions of gut microbiota and identification of the actual pathogenic flora during complications in patients undergoing kidney transplantation can help physicians develop strategies to restore the normal intestinal microbiome of transplant patients to maximize their survival and improve their quality of life.

Keywords: complication; diarrhea; gut microbiota; kidney transplantation; probiotic; rejection.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Clustering correlation between kidney transplantation and gut microbiota in published literature. (A) Analytical, diagnostic, and therapeutic techniques and equipment categories. (B) Phenomena and processes categories. (C) Diseases category. (D) Organisms category.
Figure 2
Figure 2
The primary mechanism underlying kidney damage after gut microbiota disorders.
Figure 3
Figure 3
Schematic view of the link between gut microbiota and kidney transplantation complications. The red apples represent an upward trend in the abundance of gut microbiota. The green apples represent a downward trend in the abundance of gut microbiota.
See this image and copyright information in PMC

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