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Multicenter Study
. 2023 Jun 6:14:1177127.
doi: 10.3389/fimmu.2023.1177127. eCollection 2023.

Emerging trends and research foci of neuromyelitis optica spectrum disorder: a 20-year bibliometric analysis

Yue Su  1 , Zhe Ruan  1 , Shicao Li  2 , Zhuyi Li  1 , Ting Chang  1
Affiliations
Multicenter Study

Emerging trends and research foci of neuromyelitis optica spectrum disorder: a 20-year bibliometric analysis

Yue Su et al. Front Immunol. .

Abstract

Background: Neuromyelitis optica spectrum disorder (NMOSD) is a demyelinating syndrome of the central nervous system. A tremendous amount of literature on NMOSD has been published. This study aimed to perform a bibliometric analysis of the publications on NMOSD and show its hotspots and development trends.

Methods: We used the Web of Science Core Collection as a database and searched the literature published between 2002 and 2022. CiteSpace, VOSviewer, online bibliometric platform, and R-bibliometrix were used to conduct bibliometric analysis and network visualization, including the number of publications, citations, countries/regions, institutions, journals, authors, references, and keywords.

Results: A total of 3,057 publications on NMOSD were published in 198 journals by 200 authors at 200 institutions from 93 countries/regions. The United States published the most literature and made great contributions to this field. The Mayo Clinic was the institution with the largest number of publications. The journal with the most publications was Multiple Sclerosis and Related Disorders, and the most co-cited journal was Neurology. The author with the most publications was Fujihara, K., while the most frequently co-cited author was Wingerchuk, DM. The current research hotspots may be focused on "efficacy," "multicenter," "interleukin-6 receptor blockade," "safety," "azathioprine," "tolerance," and "adult".

Conclusion: This study was the first bibliometric analysis of publications on the NMOSD field, visualizing its bibliometric characteristics and gaining insight into the direction, hotspots, and development of global NMOSD research, which may provide helpful information for researchers. Future research hotspots might be conducting randomized controlled trials on targeted immunotherapy in the NMOSD field.

Keywords: Citespace; NMOSD; VOSviewer; bibliometric; neuromyelitis optica spectrum disorder.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the literature search and screening in the study.
Figure 2
Figure 2
The annual publications and citations of NMOSD articles from 2002 to 2022.
Figure 3
Figure 3
(A) The changing trend of the annual publication quantity in the top 10 countries/regions from 2002 to 2022; (B) Geographic distribution map of different countries/regions in the NMOSD field; (C) The international collaboration visualization map of countries/regions; (D) Network visualization showing the relationship between countries.
Figure 4
Figure 4
The network visualization of the citation analysis of the institutions.
Figure 5
Figure 5
(A) The network visualization of the co-authorship analysis of the authors. (B) The overlay visualization map of author citation analysis based on VOSviewer. The purple nodes represent the authors that participated in the early research in this field, while the yellow nodes reflect the authors who engaged in later research.
Figure 6
Figure 6
The network visualization of the co-citation analysis of the journals.
Figure 7
Figure 7
The annual change pattern of journal frequency.
Figure 8
Figure 8
(A) The visualization of co-cited references in the NMOSD field. (B) The top 25 references with the strongest citation bursts.
Figure 9
Figure 9
(A) The overlay visualization map of the co-occurrence keywords performed by VOSviewer software. (B) The top 25 keywords with the strongest citation bursts of publications in the field of NMOSD from 2002 to 2022.
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