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. 2023 May 28;29(20):3203-3215.
doi: 10.3748/wjg.v29.i20.3203.

Global research trends on diet and nutrition in Crohn's disease

Muna Shakhshir  1 , Sa'ed H Zyoud  2   3   4
Affiliations

Global research trends on diet and nutrition in Crohn's disease

Muna Shakhshir et al. World J Gastroenterol. .

Abstract

Background: Crohn's disease represents a challenge for patients concerned with the modified diet regimen as well as practitioners who seek the best nutritional therapy. Crohn's disease can alter the body's ability to digest food and to absorb nutrients, resulting in severe vitamin deficiencies, malnutrition and sometimes life-threatening complications. However, a comprehensive bibliometric analysis is lacking to map the current links between nutrition and Crohn's disease in terms of the number of citations, geographic distribution and growth trends of publications.

Aim: To introduce the current state of research as well as hotspots in the field of nutrition and Crohn's disease from a bibliometric standpoint.

Methods: We searched the Scopus database and selected the relevant literature on nutrition and Crohn's disease that met the inclusion criteria. We analyzed the publication trends and research hotspots by using video object segmentation viewer software.

Results: We included 1237 publications. The number of documents published each year has increased steadily. The United States and the University of Otago, Christchurch, have had the highest productivity, with 208 (16.81%) and 29 (2.34%) documents, respectively. The "role of exclusive enteral nutrition for complicated Crohn's disease" and "manipulation of the gut microbiota as a key target for Crohn's disease" were the major research areas in 2016-2021, and they could be extensively investigated in the future. Meanwhile, research on "malnutrition in patients with Crohn's disease" appeared to be an area that attracted more research attention before 2016.

Conclusion: This is the first bibliometric analysis to map the knowledge structure and trends regarding nutrition in Crohn's disease research over the past two decades. The results provide a comprehensive summary and identification of the frontiers of nutrition and Crohn's disease-related research, which may be used as a resource by researchers in the field.

Keywords: Bibliometric; Crohn’s disease; Diet; Malnutrition; Microbiota; Nutrition.

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Conflict of interest statement

Conflict-of-interest statement: The authors have no financial disclosures or conflicts of interest to declare.

Figures

Figure 1
Figure 1
Growth trends of publications on nutrition and Crohn's disease from 2002 to 2021.
Figure 2
Figure 2
Network visualization map depicting international collaboration in research related to nutrition and Crohn’s disease during 2002-2021.
Figure 3
Figure 3
Analysis of the co-occurrence network of authors’ keywords. Keywords of the authors with at least 10 occurrences were analyzed.
Figure 4
Figure 4
Co-occurrence overlay visualization of the authors’ keywords. Yellow highlights indicate the most recent keywords.
See this image and copyright information in PMC

References

    1. GBD 2017 Inflammatory Bowel Disease Collaborators. The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol. 2020;5:17–30. - PMC - PubMed
    1. Danese S, Parigi TL, Peyrin-Biroulet L, Ghosh S. Defining difficult-to-treat inflammatory bowel disease: why and how. Lancet Gastroenterol Hepatol. 2021;6:520–522. - PubMed
    1. Jairath V, Feagan BG. Global burden of inflammatory bowel disease. Lancet Gastroenterol Hepatol. 2020;5:2–3. - PubMed
    1. Adamji M, Day AS. An overview of the role of exclusive enteral nutrition for complicated Crohn’s disease. Intest Res. 2019;17:171–176. - PMC - PubMed
    1. Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, Sung JJY, Kaplan GG. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390:2769–2778. - PubMed