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Review
. 2023 Jun 2;9(6):e16773.
doi: 10.1016/j.heliyon.2023.e16773. eCollection 2023 Jun.

Recent medicinal approaches of novel pyrimidine analogs: A review

Sharanabasappa B Patil  1
Affiliations
Review

Recent medicinal approaches of novel pyrimidine analogs: A review

Sharanabasappa B Patil. Heliyon. .

Abstract

Pyrimidine derivatives attract researchers due to their versatile scaffold & their medicinal significance. Pyrimidine associated analogs are majorly contributed to the field of medicinal chemistry. In this review article, the recent new structural design and development of active agent studies and biological approaches are highlighted. In addition, the biological potency and the structure-activity relationship of pyrimidines such as antimicrobial, anticancer, anti-inflammatory, analgesic, anti-diabetic, anti-HIV, anthelmintic, CNS depressants, and cardiac agents are discussed. Finally, this review article may attract the researchers for new structural design and development of novel active pyrimidine scaffolds with more active and less harmful.

Keywords: Pyrimidine derivatives; SAR & medicinal significance.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Molecular structures of pyrimidine with antimicrobial potential.
Fig. 2
Fig. 2
Molecular structures of pyrimidine with antimicrobial potential.
Fig. 3
Fig. 3
Molecular structures of pyrimidine with anticancer potential.
Fig. 4
Fig. 4
Molecular structures of pyrimidine with anticancer potential.
Fig. 5
Fig. 5
Molecular structures of pyrimidine with analgesic potential.
Fig. 6
Fig. 6
Molecular structures of pyrimidine with analgesic and anti-inflammatory potential. Naglaa Mohamed Ahmed et al., 2020. Prepared new pyrimidine analogs and tested them for antiinflammatory potential. Among all compounds (21), (22) & (23) exhibited 61–86% antiinflammatory potency compared with standard (Ibuprofen, 69%) at 1 h interval postcarrageenan range from 22 to 74%. The enhanced activity may be due to the presence of thienopyrimidine moiety [27].
Fig. 7
Fig. 7
Molecular structures of pyrimidine with antioxidant potential.
Fig. 8
Fig. 8
Molecular structures of pyrimidine with antioxidant potential.
Fig. 9
Fig. 9
Molecular structures of pyrimidine as cardiac agents.
Fig. 10
Fig. 10
Molecular structures of pyrimidine as antidiabetic agents.
Fig. 11
Fig. 11
Molecular structures of pyrimidine with anti-HIV potential.
Fig. 12
Fig. 12
Structures of pyrimidine with anthelmintic potential.
Fig. 13
Fig. 13
Molecular structures of pyrimidine with CNS depressant potential.
Fig. 14
Fig. 14
Molecular structures of pyrimidine with anxiolytic potential.
Fig. 15
Fig. 15
Commercially available pyrimidine scaffold associated drugs.
See this image and copyright information in PMC

References

    1. Wenneng Wu, et al. Synthesis and antifungal activity of pyrimidine derivatives containing an amide moiety. Front. Chem. 2021;9 doi: 10.3389/fchem.2021.695628. - DOI - PMC - PubMed
    1. Samvel N.S., et al. Synthesis and antimicrobial activity of new amino derivatives of pyrano[4’’,3’’:4’,5’]pyrido[3’,2’:4,5]thieno[3,2-d]pyrimidine. An Acad. Bras Ciências. 2018;90(1 Suppl. 2):1043–1057. doi: 10.1590/0001-3765201820170798. - DOI - PubMed
    1. Safinaz, et al. Synthesis and anticancer activity of some pyrido[2,3-d]pyrimidine derivatives as apoptosis inducers and cyclin-dependent kinase inhibitors. Future Med. Chem. 2019;11(18):2395–2414. doi: 10.4155/fmc-2019-0050. - DOI - PubMed
    1. Haroon ur Rashid, et al. Research developments in the syntheses, anti-inflammatory activities and structure–activity relationships of pyrimidines. RSC Adv. 2021;11:6060–6098. doi: 10.1039/D0RA10657G. - DOI - PMC - PubMed
    1. Mohammad M.A., et al. Synthesis, characterization, docking study and biological evaluation of new chalcone, pyrazoline, and pyrimidine derivatives as potent antimalarial compounds. Arab. J. Chem. 2021;14 doi: 10.1016/j.arabjc.2021.103304. - DOI

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