Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 May-Jun;27(3):332-335.
doi: 10.4103/jisp.jisp_306_22. Epub 2023 May 1.

Synthetic mineral collagen composite bone graft with ribose cross linked collagen membrane for lateral ridge augmentation

Ashwin Parakkaje Subramanya  1 , M L V Prabhuji  1
Affiliations
Case Reports

Synthetic mineral collagen composite bone graft with ribose cross linked collagen membrane for lateral ridge augmentation

Ashwin Parakkaje Subramanya et al. J Indian Soc Periodontol. 2023 May-Jun.

Abstract

A combination of calcium phosphate-based mineral with carbon apatite structure and type 1 collagen derived from bovine Achilles tendon has been introduced for augmentation of alveolar ridge and periodontal defects. Carbon apatite structure of mineral mimics natural bone in terms of resorption and remodeling, while collagen provides three-dimensional structure; both together aid in higher osteoconduction. The aim of present case report was to investigate if synthetic mineral collagen composite bone graft (CBG) with ribose cross-linked collagen membrane (RCLM) may be successfully used to obtain lateral augmentation of alveolar ridge that is planned for dental implant placement. Lateral augmentation of ridge was performed by elevating a full-thickness mucoperiosteal flap, followed by debridement and decortication of the defect area. CBG was soaked in saline and molded onto the defect area. RCLM was used to cover the graft site, followed by stabilization of membrane and the flap by suturing. Preoperative and postoperative ridge widths were measured using cone-beam computed tomography scans. The use of synthetic mineral collagen CBG with RCLM for lateral ridge augmentation may lead to increase in ridge width making it suitable for dental implant placement.

Keywords: Bone augmentation; bone grafts; guided bone regeneration; lateral bone augmentation.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
(a) Preoperative cone-beam computed tomography scan; (b) postoperative cone-beam computed tomography scan
Figure 2
Figure 2
Steps in lateral bone augmentation. (a) Preoperative bone defect; (b) preoperative lateral bone width visualized clinically; (c) mucoperiosteal flap reflection and visualization of residual alveolar ridge; (d) decortication performed; (e) synthetic mineral collagen composite bone graft; (f) adaptation of synthetic mineral collagen composite bone graft on the ridge defect; (g) placement of ribose cross-linked collagen membrane over the grafted region; (h) stabilization of membrane and approximation of flap
Figure 3
Figure 3
Re-entry procedure – Implant placement. (a and b) Alveolar ridge at 6-month postoperative to lateral bone augmentation; (c) Mucoperiosteal flap reflection and visualization of residual alveolar ridge; (d) placement of paralleling pin after implant osteotomy; (e) placement of dental implant; (f) suturing and closure of flap
Figure 4
Figure 4
Histopathology of bone sample obtained from augmented site (×20) – viable bone noted
See this image and copyright information in PMC

References

    1. Donos N, Mardas N, Chadha V. Clinical outcomes of implants following lateral bone augmentation: Systematic assessment of available options (barrier membranes, bone grafts, split osteotomy) J Clin Periodontol. 2008;35:173–202. - PubMed
    1. Zhang X, Atsuta I, Narimatsu I, Ueda N, Takahashi R, Egashira Y, et al. Replacement process of carbonate apatite by alveolar bone in a rat extraction socket. Materials (Basel) 2021;14:4457. - PMC - PubMed
    1. Matsuura A, Kubo T, Doi K, Hayashi K, Morita K, Yokota R, et al. Bone formation ability of carbonate apatite-collagen scaffolds with different carbonate contents. Dent Mater J. 2009;28:234–42. - PubMed
    1. Itoh M, Shimazu A, Hirata I, Yoshida Y, Shintani H, Okazaki M. Characterization of CO3Ap-collagen sponges using X-ray high-resolution microtomography. Biomaterials. 2004;25:2577–83. - PubMed
    1. Hirata I, Nomura Y, Ito M, Shimazu A, Okazaki M. Acceleration of bone formation with BMP2 in frame-reinforced carbonate apatite-collagen sponge scaffolds. J Artif Organs. 2007;10:212–7. - PubMed

Publication types