Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan-Feb;14(1):167-170.
doi: 10.32598/bcn.2021.3220.1. Epub 2023 Jan 1.

Gut Microbiota and Neuropsychiatric Disorders

Reza Bidaki  1 , Seyed Hossein Hekmati Moghaddam  2 , Maryam Sadeh  3
Affiliations

Gut Microbiota and Neuropsychiatric Disorders

Reza Bidaki et al. Basic Clin Neurosci. 2023 Jan-Feb.

Abstract

Numerous studies in humans and animals hypothesize that gut microbiota dysbiosis is involved in the development of behavioral and neurological diseases such as depression, autism spectrum disorder, Parkinson disease, multiple sclerosis, stroke and Alzheimer's disease. Some of the most salient works so far regarding the brain-gut axis are mentioned below. The current knowledge on the impact of gut microbiota on nervous system diseases is far from being directly used for pharmacologic or nutritional advice toward restoration of normal bodily functions. It seems that a more comprehensive approach should be followed so that the individual effect of each kind of intervention on the patient's somatic or psychological status is determined. Future research must address global need for regimens which could reestablish normal composition of gut microorganisms after each neuropsychological disorder.

Keywords: Alzheimer's disease; Autism spectrum disorder; Brain-gut axis; Microbiota; Nervous system diseases; Parkinson disease.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest The authors declared no conflict of interest.

References

    1. Berer K., Gerdes L. A., Cekanaviciute E., Jia X., Xiao L., Xia Z., et al. (2017). Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proceedings of the National Academy of Sciences of the United States of America, 114(40), 10719–10724. [DOI:10.1073/pnas.1711233114] [PMID] - DOI - PMC - PubMed
    1. Blacher E., Bashiardes S., Shapiro H., Rothschild D., Mor U., Dori-Bachash M., et al. (2019). Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature, 572(7770), 474–480. [DOI:10.1038/s41586-019-1443-5] [PMID] - DOI - PubMed
    1. Bonfili L., Cecarini V., Berardi S., Scarpona S., Suchodolski J. S., Nasuti C., et al. (2017). Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels. Scientific Reports, 7(1), 2426. [DOI:10.1038/s41598-017-02587-2] [PMID] [PMCID] - DOI - PMC - PubMed
    1. Borre Y. E., O'Keeffe G. W., Clarke G., Stanton C., Dinan T. G., Cryan J. F. (2014). Microbiota and neurodevelopmental windows: Implications for brain disorders. Trends in Molecular Medicine, 20(9), 509–518. [DOI:10.1016/j.molmed.2014.05.002] [PMID] - DOI - PubMed
    1. Buffington S. A., Di Prisco G. V., Auchtung T. A., Ajami N. J., Petrosino J. F., Costa-Mattioli M. (2016). Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring. Cell, 165(7), 1762–1775. [DOI:10.1016/j.cell.2016.06.001] [PMID] [PMCID] - DOI - PMC - PubMed

LinkOut - more resources