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. 2023 Oct;60(10):1359-1363.
doi: 10.1007/s00592-023-02123-x. Epub 2023 Jun 22.

The association between a single abnormal glucose and fetal c-peptide

Samantha de Los Reyes  1 , Annie Dude  2 , Jennifer Doll  3 , Beth A Plunkett  4
Affiliations

The association between a single abnormal glucose and fetal c-peptide

Samantha de Los Reyes et al. Acta Diabetol. 2023 Oct.

Abstract

Aim: We aimed to evaluated if fetuses of subjects with one elevated value on the 3-h GTT had a measurable physiologic difference in fetal C-peptide levels as compared to those with no elevated values on the GTT.

Methods: We performed a prospective cohort study to evaluate insulin levels in singleton non-anomalous fetuses of subjects with one elevated value on the GTT as compared to subjects with no elevated values on their GTT. Fetal insulin levels were measured by fetal C-peptide in cord blood. Distribution of data was assessed and outliers representing values > the 99th and < the 1st percentiles were excluded. Data were log transformed to achieve normal distribution and univariable analyses were performed to compare fetal C-peptide levels, baseline maternal characteristics and perinatal outcomes in subjects with one elevated value as compared those with no elevated values.

Results: Our analysis included 99 subjects, with 49 subjects in the one elevated value group and 50 subjects in the no elevated values group. Fetal C-peptide levels (picomoles per liters, pmol/L), were significantly higher in the elevated value group as compared to the no elevated value group (mean ± SD; 4.6 ± 0.8 vs. 4.3 ± 0.7, P = 0.046, respectively). In univariable analysis, there was no significant difference in maternal characteristics or adverse composite perinatal outcomes.

Conclusion: Fetuses of subjects who had one elevated value on their GTT had a measurable physiologic difference in C-peptide levels as compared to fetuses of subjects with no elevated values on the GTT.

Keywords: Fetal C-peptide; Fetal insulin; Gestational diabetes; Glucose tolerance test; Single elevated value.

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References

    1. Correa A, Bardenheier B, Elixhauser A, Geiss LS, Gregg E (2015) Trends in prevalence of diabetes among delivery hospitalizations, United States, 1993–2009. Matern Child Health J 19(3):635–642. https://doi.org/10.1007/s10995-014-1553-5 - DOI - PubMed - PMC
    1. Zhu Y, Hedderson MM, Quesenberry CP, Feng J, Ferrara A (2018) Central obesity increases the risk of gestational diabetes partially through increasing insulin resistance. Obesity. https://doi.org/10.1002/oby.22339 - DOI - PubMed
    1. American Diabetes Association (2004) Gestational diabetes mellitus. Diabetes Care 27(Suppl 1):S88-90 - DOI
    1. Chu SY, Callaghan WM, Kim SY et al (2007) Maternal obesity and risk of gestational diabetes mellitus. Diabetes Care 30(8):2070–2076. https://doi.org/10.2337/dc06-2559a - DOI - PubMed
    1. Thorpe LE, Berger D, Ellis JA et al (2005) Trends and racial/ethnic disparities in gestational diabetes among pregnant women in New York City, 1990–2001. Am J Public Health. https://doi.org/10.2105/AJPH.2005.066100 - DOI - PubMed - PMC

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