Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep:199:110900.
doi: 10.1016/j.apradiso.2023.110900. Epub 2023 Jun 14.

Evaluation of factors with potential influence on [18F]FDG radiochemical synthesis yield

Maja Chochevska  1 , Maja Velichkovska  2 , Marija Atanasova Lazareva  2 , Katerina Kolevska  2 , Filip Jolevski  3 , Jasmina Razmoska  3 , Zlatko Filipovski  3 , Sasho Nikolovski  4 , Marina Zdraveska Kocovska  3 , Ana Ugrinska  5
Affiliations
Free article

Evaluation of factors with potential influence on [18F]FDG radiochemical synthesis yield

Maja Chochevska et al. Appl Radiat Isot. 2023 Sep.
Free article

Abstract

[18F]FDG radiopharmaceutical production is performed with automatic synthesis modules, which enables to carry out the production process safely, reliably and reproducibly. This study aimed to investigate the factors which may influence and give inconsistent radiochemical synthesis yield, as well as common pitfalls in the synthesis process which can occur. We evaluated more than 500 batches in the overall study. The results confirmed that irradiation parameter affect the production yield of the final product, also transport capillary capability and some synthesis factors have an impact on [18F]FDG radiochemical synthesis yield.

Keywords: Fluorine-18; Pitfalls; Radioactivity; Radiosynthesis; Yield.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

LinkOut - more resources