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. 2023 Jul 3;64(1):ezad244.
doi: 10.1093/ejcts/ezad244.

Tracheal cancer: a rare and deadly but potentially curable disease that also affects younger people

Yngvar Nilssen  1 , Steinar Solberg  1   2 , Odd Terje Brustugun  3   4 , Bjørn Møller  1 , Arve Sundset  5 , Sissel Gyrid Freim Wahl  6 , Åslaug Helland  4   7
Affiliations

Tracheal cancer: a rare and deadly but potentially curable disease that also affects younger people

Yngvar Nilssen et al. Eur J Cardiothorac Surg. .

Abstract

Objectives: The incidence of tracheal cancer is low, few clinicians get much experience and the awareness may be low. Recent data on the treatment and outcome are limited. The aim of the present study was to present updated, national data on the incidence, characteristics, treatment and outcome for patients with tracheal cancer.

Methods: All tracheal cancers registered at the Cancer Registry of Norway in 2000-2020 were extracted. The patient and tumour characteristics age, sex, stage, histology and treatment modality (surgery and radiotherapy) were examined. Overall, median and relative survival were estimated. Cox regression models were used to identify independent prognostic factors.

Results: The 77 patients diagnosed with tracheal cancer equals a crude incidence rate and an age-standardized incidence rate of 0.075 and 0.046 per 100,000 per year respectively. The mean age was 63.8 years (range: 26-94). The numerical preponderance of men (n = 41) is not statistically significant. Eighteen patients (23.4%) were diagnosed in the localized stage. The 5-year overall survival was 31.7% [95% confidence interval (CI): 21.0-42.9], and in those treated with surgical resection or curative radiotherapy, it was 53.7% (95% CI: 26.1-75.0) and 37.8% (95% CI: 18.8-56.7), respectively. Age, histological type and treatment modality were identified as independent prognostic factors.

Conclusions: Despite improved survival, the prognosis for patients with tracheal cancer is still poor. Few are diagnosed in the early stage and thus most are not eligible for curative treatment, mainly surgery. An increased awareness and diagnosis in the earlier stage is crucial.

Keywords: Cancer; Epidemiology; Oncology; Surgery; Survival; Trachea.

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Figures

Figure 1:
Figure 1:
The proportions treated with the different modalities, by age group. The percentages are calculated with the number in each age group as denominator.
Figure 2:
Figure 2:
The overall survival as Kaplan–Meier estimates, stratified by treatment modality.
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References

    1. Kurien G, Cole I.. Primary carcinoma of the trachea. Clin Otolaryngol Allied Sci 1981;6:197–204. - PubMed
    1. Manninen MP, Antila PJ, Pukander JS, Karma PH.. Occurrence of tracheal carcinoma in Finland. Acta Otolaryngol 1991;111:1162–9. - PubMed
    1. Honings J, van Dijck JA, Verhagen AF, van der Heijden HF, Marres HA.. Incidence and treatment of tracheal cancer: a nationwide study in the Netherlands. Ann Surg Oncol 2007;14:968–76. - PubMed
    1. Nouraei SM, Middleton SE, Nouraei SA, Virk JS, George PJ, Hayward M. et al. Management and prognosis of primary tracheal cancer: a national analysis. Laryngoscope 2014;124:145–50. - PubMed
    1. Honings J, Gaissert HA, Verhagen AF, van Dijck JA, van der Heijden HF, van Die L. et al. Undertreatment of tracheal carcinoma: multidisciplinary audit of epidemiologic data. Ann Surg Oncol 2009;16:246–53. - PubMed

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