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. 2024 Jan;47(1):14-20.
doi: 10.1111/jvp.13399. Epub 2023 Jun 23.

Pharmacokinetics of oral tapentadol in cats

J Lakritz  1 , T K Aarnes  1 , B Alva  1 , J Howard  1 , G Magnin  2 , P Lerche  1 , B Kukanich  2
Affiliations

Pharmacokinetics of oral tapentadol in cats

J Lakritz et al. J Vet Pharmacol Ther. 2024 Jan.

Abstract

To evaluate pharmacokinetics of one dose of tapentadol hydrochloride orally administered to cats. Prospective experimental study. Five healthy adult mixed-breed cats. Each cat received 18.8 ± 1.0 mg/kg tapentadol orally. Venous blood samples were collected at time 0 (immediately prior to administration of tapentadol) 1, 2, 5, 10, 15, 30, 45, 60, 90 min, and 2, 4, 8, 12 to 24 h after drug administration. Plasma tapentadol concentrations and its metabolites were determined using ultra-performance liquid chromatography-tandem mass spectrometry. Geometric mean Tmax of tapentadol, desmethyltapentadol, tapentadol-O-glucuronide, and tapentadol-O-sulfate was 2.3, 7.0, 6.0, and 4.6 h, respectively. Mean Cmax of tapentadol, desmethyltapentadol, tapentadol-O-glucuronide, and tapentadol-O-sulfate was 637, 66, 1134, and 15,757 ng/mL, respectively, after administration. Mean half-life of tapentadol, desmethyltapentadol, tapentadol-O-glucuronide, and tapentadol-O-sulfate was 2.4, 4.7, 2.9, and 10.8 h. The relative exposure of tapentadol and its metabolites were tapentadol 2.65%, desmethyltapentadol 0.54%, tapentadol-O-glucuronide 6.22%, and tapentadol-O-sulfate 90.6%. Tapentadol-O-sulfate was the predominant metabolite following the administration of oral tapentadol in cats. Further studies are warranted to evaluate the association of analgesia with plasma concentrations of tapentadol.

Keywords: cats; opioids; pharmacokinetics; tapentadol.

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References

REFERENCES

    1. Adrian, D., Papich, M., Baynes, R., Murrell, J., & Lascelles, B. D. X. (2017). Chronic maladaptive pain in cats: A review of current and future drug treatment options. Veterinary Journal, 230, 52-61.
    1. Barbosa, J., Faria, J., Queirós, O., Moreira, R., Carvalho, F., & Dinis-Oliveira, R. J. (2016). Comparative metabolism of tramadol and tapentadol: A toxicological perspective. Drug Metabolism Reviews, 48, 577-592.
    1. Bernstein, P. (2005). The human-cat relationship. In I. Rochlitz (Ed.), The welfare of cats (pp. 47-89). Springer.
    1. Connor, J., Christie, R., Harris, E., Penning, J., & McVicar, J. (2019). Tramadol and tapentadol: Clinical and pharmacologic review. Anaesthesia Tutorial of the Week, 407, 1-6.
    1. Doodnaught, G., Evangelista, M. C., & Steagall, P. (2017). Thermal antinociception following oral administration of tapentadol in conscious cats. Veterinary Anaesthesia and Analgesia, 44, 364-369.

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