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. 2023 Aug;40(8):775-783.
doi: 10.1111/echo.15640. Epub 2023 Jun 23.

Inter-center reproducibility of standard and advanced echocardiographic parameters in the EACVI-AFib echo registry

Ciro Santoro  1 , Erwan Donal  2 , Julien Magne  3 , Leyla Elif Sade  4 , Martin Penicka  5 , Asim Katbeh  5 , Bernard Cosyns  6 , Matteo Cameli  7 , Jadranka Separovic Hanzevacki  8 , Vlatka Reskovic Luksic  8 , Eustachio Agricola  9 , Rodolfo Citro  10   11 , Andreas Hagendorff  12 , Patrizio Lancellotti  13   14 , Gilbert Habib  15 , Antonella Moreo  16 , Nuno Cardim  17 , Vito Maurizio Parato  18 , Alexsandar Neskovic  19 , Monica Rosca  20 , Elena Galli  3 , Andreea Motoc  6 , Giulia Mandoli  7 , Giacomo Ingallina  9 , Costantina Prota  10 , Stephen Stoebe  12 , Caroline Piette  13 , Basile Mouhat  15 , Andreina Carbone  15   21 , Benedetta De Chiara  16 , Federica Ilardi  1 , Ivan Stankovic  19 , Jose Luis Zamorano  22 , Bogdan Alexandru Popescu  20 , Thor Edvardsen  23 , Maurizio Galderisi  1
Affiliations
Free article

Inter-center reproducibility of standard and advanced echocardiographic parameters in the EACVI-AFib echo registry

Ciro Santoro et al. Echocardiography. 2023 Aug.
Free article

Abstract

Aim: we sought to test the inter-center reproducibility of 16 echo laboratories involved in the EACVI-Afib Echo Europe.

Methods: This was done on a dedicated setting of 10 patients with sinus rhythm (SR) and 10 with persistent atrial fibrillation (AF), collected by the Principal Investigator. Images and loops of echo-exams were stored and made available for labs. The tested measurements included main echo-Doppler parameters, global longitudinal strain (GLS) and peak atrial longitudinal strain (PALS).

Results: Single measures interclass correlation coefficients (ICCs) of left ventricular mass and ejection fraction were suboptimal in both patients with SR and AF. Among diastolic parameters, ICCs of deceleration time were poor, in particular in AF (=.50). ICCs of left atrial size and function, besides optimal in AF, showed an acceptable despite moderate concordance in SR. ICC of GLS was .81 and .78 in SR and AF respectively. ICCs of PALS were suitable but lower in 4-chamber than in 2-chamber view. By depicting the boxplot of the 16 laboratories, GLS distribution was completely homogeneous in SR, whereas GLS of AF and PALS of both SR and AF presented a limited number of outliers. GLS mean ± SE of the 16 labs was 19.7 ± .36 (95% CI: 18.8-20.4) in SR and 16.5 ± .29 (95% CI: 15.9-17.1) in AF, whereas PALS mean ± SE was 43.8 ± .70 (95% CI: 42.3-45.3) and 10.2 ± .32 (95% CI: 9.5-10.9) respectively.

Conclusion: While the utilization of some standard-echo variables should be discouraged in registries, the application of GLS and PALS could be largely promoted because their superior reproducibility, even in AF.

Keywords: ejection fraction; global longitudinal strain; left ventricular mass; peak atrial longitudinal strain; registry; reproducibility.

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References

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