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. 2023 Jun 23;80(8):251.
doi: 10.1007/s00284-023-03357-2.

Antifungal Activity of Nanobiocomposite Films Based on Silver Nanoparticles Obtained Through Green Synthesis

Eduardo José Juca Mallmann  1 , Francisco Afrânio Cunha  1   2 , Enzo Victorino Hernandez Agressott  3 , Fernando Lima de Menezes  1 , Rita de Cássia Carvalho Barbosa  2 , Roxeane Teles Martins  4 , Maria da Conceição Dos Santos Oliveira Cunha  5   6 , Maria Veraci Oliveira Queiroz  5 , Henrique Douglas Melo Coutinho  7 , John Eversong Lucena de Vasconcelos  8 , Pierre Basílio Almeida Fechine  9
Affiliations

Antifungal Activity of Nanobiocomposite Films Based on Silver Nanoparticles Obtained Through Green Synthesis

Eduardo José Juca Mallmann et al. Curr Microbiol. .

Abstract

The high incidence of Candida albicans infections has raised concerns regarding side effects and drug resistance, compounded by a limited number of alternative drugs. Silver nanoparticles (AgNPs) have prominent antimicrobial activity, but effective administration remains a challenge. In this study, AgNPs were synthesized via a green chemistry approach, using glucose as a reducing agent, and incorporated into an agar matrix to form a film (AgFilm). The AgNPs and AgFilm were characterized by Ultraviolet-visible (UV-vis) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), and atomic force microscopic (AFM). The UV-Vis spectra of the AgNPs and AgFilm showed bands at 415 and 413 nm, respectively. The PXRD and UV-Vis data suggest that the growth of AgNPs was effectively inhibited in the AgFilm. The diameter of AgNPs dispersed in AgFilm was 76 ± 42 nm, and the thickness of the film and 35 ± 3 µm. The antifungal activity of AgFilm was evaluated against 20 strains of C. albicans, demonstrating high antifungal activity with an inhibition zone of 19 ± 2 mm. Therefore, AgFilm could be a promising option for the treatment of superficial C. albicans infections.

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References

    1. Rayens E, Norris KA (2022) Prevalence and healthcare burden of fungal infections in the United States, 2018. Open Forum Infect Dis. https://doi.org/10.1093/OFID/OFAB593 - DOI - PubMed - PMC
    1. Zhou L, Zhao X, Li M et al (2021) Antifungal activity of silver nanoparticles synthesized by iturin against Candida albicans in vitro and in vivo. Appl Microbiol Biotechnol 105:3759–3770. https://doi.org/10.1007/S00253-021-11296-W/FIGURES/8 - DOI - PubMed
    1. Jia D, Sun W (2021) Silver nanoparticles offer a synergistic effect with fluconazole against fluconazole-resistant Candida albicans by abrogating drug efflux pumps and increasing endogenous ROS. Infect Genet Evol 93:104937. https://doi.org/10.1016/J.MEEGID.2021.104937 - DOI - PubMed
    1. Nadhe SB, Singh R, Wadhwani SA, Chopade BA (2019) Acinetobacter sp. mediated synthesis of AgNPs, its optimization, characterization and synergistic antifungal activity against C. albicans. J Appl Microbiol 127:445–458. https://doi.org/10.1111/JAM.14305 - DOI - PubMed
    1. Soumbo M, Scarangella A, Villeneuve-Faure C et al (2020) Combined effect of proteins and AgNPs on the adhesion of yeast Candida albicans on solid silica surfaces. Proc IEEE Conf Nanotechnol. https://doi.org/10.1109/NANO47656.2020.9183494 - DOI

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