Tektin makes a microtubule a "micropillar"

Yuzhong Gu¹, Yimeng Zhao², Muneyoshi Ichikawa³

Affiliations

¹ State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.
² State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai 200438, China; Human Phenome Institute, Fudan University, Shanghai 200438, China.
³ State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China. Electronic address: ichikawa_muneyoshi@fudan.edu.cn.

PMID: 37352832
DOI: 10.1016/j.cell.2023.05.018

Free article

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Tektin makes a microtubule a "micropillar"

Yuzhong Gu et al. Cell. 2023.

Free article

. 2023 Jun 22;186(13):2725-2727.

doi: 10.1016/j.cell.2023.05.018.

Authors

Yuzhong Gu¹, Yimeng Zhao², Muneyoshi Ichikawa³

Affiliations

¹ State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.
² State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai 200438, China; Human Phenome Institute, Fudan University, Shanghai 200438, China.
³ State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China. Electronic address: ichikawa_muneyoshi@fudan.edu.cn.

PMID: 37352832
DOI: 10.1016/j.cell.2023.05.018

Abstract

Inside sperm flagella, there are nine doublet microtubules composed of A and B tubules. In this issue of Cell, Leung et al. and Zhou et al. present high-resolution cryo-EM structures of doublet microtubules from mammalian sperms and show unprecedented structures of the A tubules, which are almost entirely occupied with tektin bundles.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility.
Zhou L, Liu H, Liu S, Yang X, Dong Y, Pan Y, Xiao Z, Zheng B, Sun Y, Huang P, Zhang X, Hu J, Sun R, Feng S, Zhu Y, Liu M, Gui M, Wu J. Zhou L, et al. Cell. 2023 Jun 22;186(13):2897-2910.e19. doi: 10.1016/j.cell.2023.05.009. Epub 2023 Jun 8. Cell. 2023. PMID: 37295417
Structural specializations of the sperm tail.
Leung MR, Zeng J, Wang X, Roelofs MC, Huang W, Zenezini Chiozzi R, Hevler JF, Heck AJR, Dutcher SK, Brown A, Zhang R, Zeev-Ben-Mordehai T. Leung MR, et al. Cell. 2023 Jun 22;186(13):2880-2896.e17. doi: 10.1016/j.cell.2023.05.026. Epub 2023 Jun 15. Cell. 2023. PMID: 37327785 Free PMC article.

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Tektin makes a microtubule a "micropillar"

Affiliations

Tektin makes a microtubule a "micropillar"

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Conflict of interest statement

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