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Comment
. 2023 Jun 22;186(13):2728-2730.
doi: 10.1016/j.cell.2023.05.029.

A sound mind in a sound body: Stress-induced glucocorticoids exacerbate gut inflammation

Haitham Hajjo  1 , Dror S Shouval  2 , Tal Gefen  3 , Naama Geva-Zatorsky  4
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A sound mind in a sound body: Stress-induced glucocorticoids exacerbate gut inflammation

Haitham Hajjo et al. Cell. .
Free article

Abstract

The notion that psychological stress can deteriorate our health is widely accepted. However, the mechanisms at play are poorly understood. In this issue of Cell, Schneider et al. identify the impact of glucocorticoids on enteric glia and neurons and elucidate the underlying mechanisms that link psychological stress to the exacerbation of gut inflammation.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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  • The enteric nervous system relays psychological stress to intestinal inflammation.
    Schneider KM, Blank N, Alvarez Y, Thum K, Lundgren P, Litichevskiy L, Sleeman M, Bahnsen K, Kim J, Kardo S, Patel S, Dohnalová L, Uhr GT, Descamps HC, Kircher S, McSween AM, Ardabili AR, Nemec KM, Jimenez MT, Glotfelty LG, Eisenberg JD, Furth EE, Henao-Mejia J, Bennett FC, Pierik MJ, Romberg-Camps M, Mujagic Z, Prinz M, Schneider CV, Wherry EJ, Bewtra M, Heuckeroth RO, Levy M, Thaiss CA. Schneider KM, et al. Cell. 2023 Jun 22;186(13):2823-2838.e20. doi: 10.1016/j.cell.2023.05.001. Epub 2023 May 25. Cell. 2023. PMID: 37236193 Free PMC article.

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