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. 2023 Jul;68(7):998-1012.
doi: 10.4187/respcare.10876.

Oxygen Therapy in COPD

Michael W Hess  1
Affiliations

Oxygen Therapy in COPD

Michael W Hess. Respir Care. 2023 Jul.

Abstract

Long-term oxygen therapy (LTOT) is a mainstay treatment for patients with severe resting hypoxemia secondary to chronic respiratory conditions including COPD. The evidence for LTOT is based on two trials that are now several decades old but have been insufficiently revisited. Therefore, many questions remain about precisely which patients experience the most benefit from LTOT, as well as how to define that benefit. Most studies have examined LTOT's effect on longevity rather than its impact on quality of life. In addition, many challenges exist in training both clinicians and patients on best practices for LTOT and associated equipment. Reimbursement policies have reduced the kinds of equipment available to the LTOT patient community, presenting additional challenges. This paper will review the current evidence for LTOT in COPD, the challenges involved with providing optimal therapy, and potential avenues of modernizing this essential intervention.

Keywords: COPD; long-term oxygen therapy; oxygen; oxygen concentrator; portable oxygen concentrator; quality of life; supplemental oxygen.

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Conflict of interest statement

Mr Hess has disclosed no conflicts of interest.

References

    1. Jacobs SS, Lederer DJ, Garvey CM, Hernandez C, Lindell KO, McLaughlin S, et al. . Optimizing home oxygen therapy an official American Thoracic Society workshop report. Ann Am Thorac Soc 2018;15(12):1369-1381. - PubMed
    1. Levinson DR. Medicare home oxygen equipment: cost and servicing. US Department of Health and Human Services Office of the Inspector General 2006. OEI-09-04-00420. Accessed February 7, 2023.
    1. Branson RD. Oxygen therapy in COPD. Respir Care 2018;63(6):734-748. - PubMed
    1. Kvale PA, Conway WA, Coates EO. Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease. A clinical trial. Ann Intern Med 1980;93(3):391-398. - PubMed
    1. Leggett RJ, Cooke NJ, Clancy L, Leitch AG, Kirby BJ, Flenley DC. Long-term domiciliary oxygen therapy in cor pulmonale complicating chronic bronchitis and emphysema. Thorax 1976;31(4):414-418. - PMC - PubMed