Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun 23:78:100234.
doi: 10.1016/j.clinsp.2023.100234. eCollection 2023.

A longitudinal study of the peripheral and central auditory pathways in individuals with acute lymphoid leukemia

Jéssica Sales Vosgrau  1 , Liliane Aparecida Fagundes Silva  2 , Vicente Odone Filho  3 , Carla Gentile Matas  2
Affiliations

A longitudinal study of the peripheral and central auditory pathways in individuals with acute lymphoid leukemia

Jéssica Sales Vosgrau et al. Clinics (Sao Paulo). .

Abstract

Objective: To characterize the peripheral and central auditory pathways in individuals with Acute Lymphoid Leukemia (ALL) and compare assessment results before and during chemotherapy.

Method: The study included 17 subjects with ALL, divided into two age groups: 3 to 6 (11 individuals) and 7 to 16 years old (6 individuals). Each subject was evaluated twice (before and 3 to 6 months after chemotherapy treatment) with the following procedures: medical history survey, otoscopy, Pure-Tone Threshold (PTA) and speech audiometry, acoustic immittance measures, Brainstem Auditory Evoked Potentials (BAEP) and Long-Latency Auditory Evoked Potentials (LLAEP).

Results: PTA was normal. Tympanometry was abnormal in the second assessment in 2 individuals aged 3 to 6 years. One subject in each age group had absent ipsilateral acoustic reflexes. In high-frequency audiometry, 1 individual had abnormal results. BAEP was abnormal in 5 (first assessment) and 7 individuals (second assessment) aged 3 to 6 years and 2 (first assessment) and 1 individual (second assessment) aged 7 to 16 years. As for LLAEP, P1 latency was increased in 5 (first assessment) and 7 individuals (second assessment) aged 3 to 6 years.

Conclusion: No hearing loss was identified in the behavioral audiological assessment. BAEP was more affected in the 3-to-6-year-old group, with greater impairment in the lower brainstem in the first and second assessments. In LLAEP, P1 was the most impaired component in children aged 3 to 6 years, and P2 and N2 were so for those 7 to 16 years old, especially in the second assessment.

Keywords: Auditory evoked potentials; Auditory perception; Hearing; Leukemia-lymphoblastic precursor cell lymphoma; Pharmacological treatment.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare no conflicts of interest.

Similar articles

See all similar articles

References

    1. Navarrete-Meneses M, Pérez-Vera P. Epigenetic alterations in acute lymphoblastic leukemia. Bol Med Hosp Infant Mex. 2017;74(4):243–264. - PubMed
    1. Inaba H, Pui CH. Advances in the Diagnosis and Treatment of Pediatric Acute Lymphoblastic Leukemia. J Clin Med. 2021;29(9):1926. - PMC - PubMed
    1. Pedrosa F, Lins M. Leucemia linfóide aguda: uma doença curável. Rev Bras Saude Mater Infant. 2002;2(1):63–68.
    1. Instituto Nacional de Câncer . Câncer na criança e no adolescente no Brasil. Dados dos registros de base populacional e mortalidade; Rio de Janeiro: 2008. Instituto Nacional de Câncer.
    1. Nehmy RMQ, Brito AC, Mota JAC, Oliveira BM. A perspectiva dos pais sobre a obtenção do diagnóstico de leucemia linfóide aguda em crianças e adolescentes: uma experiência no Brasil. Rev Bras Saude Mater Infant. 2011;11(3):293–299.