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. 2023 Jul-Aug:44:100373.
doi: 10.1016/j.ijmmb.2023.100373. Epub 2023 May 11.

Pattern of InhA and KatG mutations in isoniazid mono resistant Mycobacterium tuberculosis isolates from Odisha

Sujeet Kumar  1 , Sunil Swick Rout  1 , Sarita Kar  1 , Himadri Bhusan Bal  1 , Jyotirmayee Turuk  2 , Dasarathi Das  2 , Prasanta Kumar Hota  3 , Sanghamitra Pati  2 , Sidhartha Giri  4
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Pattern of InhA and KatG mutations in isoniazid mono resistant Mycobacterium tuberculosis isolates from Odisha

Sujeet Kumar et al. Indian J Med Microbiol. 2023 Jul-Aug.

Abstract

We conducted a retrospective analysis of the line probe assay (LPA) data during January to December 2019, from 8 districts of Odisha. The prevalence of Hr-TB (isoniazid resistance only) was 1.53% (50/3272) with a range of 0-3.4% in the 8 districts. Of the 50 Hr-TB strains, katG mutation and inhA mutations were seen in 74% (37/50) and 26% (13/50) strains respectively. S315T1 and C15T were common mutations in katG and inhA respectively. Since these mutations are closely related to high- or low degree resistance to INH, it has therapeutic implications.

Keywords: Isoniazid; Mutation; Mycobacterium tuberculosis; Rifampicin.

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Declaration of competing interest None.

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