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. 2023 Jul;58(4):388-394.
doi: 10.5152/TurkArchPediatr.2023.22261.

Long-Term Follow-Up and Outcome of Pediatric Acute Pancreatitis: A Multicenter Study

Burcu Volkan  1 , Bilge Şahin Akkelle  1 , Nevzat Aykut Bayrak  2 , Engin Tutar  1 , Özlem Kalaycık Şengül  1 , Esra Polat  3 , Günsel Kutluk  4 , Deniz Ertem  1
Affiliations

Long-Term Follow-Up and Outcome of Pediatric Acute Pancreatitis: A Multicenter Study

Burcu Volkan et al. Turk Arch Pediatr. 2023 Jul.

Abstract

Objective: Over the past decades, the incidence of acute pancreatitis is increasing, but the progression of acute recurrent pancreatitis and chronic pancreatitis is still not well documented in children. The aim of this multicenter study is to delineate the changes that occur in a certain time period in the course of childhood pancreatitis.

Materials and methods: The data of consecutive patients hospitalized with acute pancreatitis between 2010 and 2017 in 4 different pediatric gastroenterology units were reviewed. The clini- cal characteristics of the disease were defined.

Results: A total of 165 patients (55.2% female) were included. Over the years, the rate of acute pancreatitis admissions increased while the duration of hospitalization decreased (P < .05). Nearly two-thirds of the patients with acute pancreatitis resolved spontaneously, 30.9% and 4.3% of the cases developed acute recurrent pancreatitis and chronic pancreatitis, respectively. Furthermore, 27.4% patients with acute recurrent pancreatitis progressed to chronic pancre- atitis, and eventually, 12.7% of cases developed chronic pancreatitis within 3-4 years. Local complications developed in 13.3% of the patients with pancreatitis in this cohort.

Conclusion: The result of this study confirmed the increased incidence of acute pancreatitis in recent years. Conversely, the length of hospital stay decreased over the years. Patients with pancreaticobiliary abnormalities or genetic risk factors had a higher rate of progression to acute recurrent pancreatitis or chronic pancreatitis. Therefore, genetic testing and radiological imaging should be considered early in the follow-up of patients with acute pancreatitis having risk factors for progression to acute recurrent pancreatitis/chronic pancreatitis.

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Figures

Figure 1.
Figure 1.
(A) The rate of acute pancreatitis over the years. (B) The change in length of hospital stay over the years in patients with acute pancreatitis.
Figure 2.
Figure 2.
(A) Etiological distribution of all patients with pancreatitis in the study cohort. (B) Etiological distribution of the patients in acute pancreatitis, acute recurrent pancreatitis, and chronic pancreatitis.
Figure 3.
Figure 3.
Follow-up course of the acute pancreatitis cohort.
Figure 4.
Figure 4.
Cumulative incidence of recurrent attack after the first attack (left) and chronic pancreatitis (right) in the study group.
See this image and copyright information in PMC

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