Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Oct;14(10):1157-1159.
doi: 10.1111/jdi.14047. Epub 2023 Jun 25.

Serine supplementation: Is it a new option for the treatment of diabetic polyneuropathy?

Hiroki Mizukami  1
Affiliations
Comment

Serine supplementation: Is it a new option for the treatment of diabetic polyneuropathy?

Hiroki Mizukami. J Diabetes Investig. 2023 Oct.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Decrease in serine level and diabetic peripheral neuropathy. Insufficient insulin action causes a decrease in the serine level of serum and of several organs. A decrease in serine and an application of high‐fat diet promote the production of deoxydihydroceramide, which is a more toxic form of ceramide, from a reaction with serine palmitoyl transferase. These changes cause and develop diabetic peripheral neuropathy. A serine supplemented diet or myriocin, a serine palmitoyl transferase inhibitor, can improve peripheral neuropathy in diabetic mice.
See this image and copyright information in PMC

Comment on

  • Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.
    Handzlik MK, Gengatharan JM, Frizzi KE, McGregor GH, Martino C, Rahman G, Gonzalez A, Moreno AM, Green CR, Guernsey LS, Lin T, Tseng P, Ideguchi Y, Fallon RJ, Chaix A, Panda S, Mali P, Wallace M, Knight R, Gantner ML, Calcutt NA, Metallo CM. Handzlik MK, et al. Nature. 2023 Feb;614(7946):118-124. doi: 10.1038/s41586-022-05637-6. Epub 2023 Jan 25. Nature. 2023. PMID: 36697822 Free PMC article.

References

    1. Holeček M. Role of impaired glycolysis in perturbations of amino acid metabolism in diabetes mellitus. Int J Mol Sci 2023; 24: 1724. - PMC - PubMed
    1. Felig P, Marliss E, Cahill GF Jr. Plasma amino acid levels and insulin secretion in obesity. N Engl J Med 1969; 281: 811–816. - PubMed
    1. Mathew AV, Jaiswal M, Ang L, et al. Impaired amino acid and TCA metabolism and cardiovascular autonomic neuropathy progression in type 1 diabetes. Diabetes 2019; 68: 2035–2044. - PMC - PubMed
    1. Handzlik MK, Gengatharan JM, Frizzi KE, et al. Insulin‐regulated serine and lipid metabolism drive peripheral neuropathy. Nature 2023; 614: 118–124. - PMC - PubMed
    1. Takeuchi Y, Mizukami H, Kudoh K, et al. The diversity and abundance of gut microbiota are associated with the pain sensation threshold in the Japanese population. Neurobiol Dis 2022; 173: 105839. - PubMed