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. 2023 Oct 3;52(38):13482-13486.
doi: 10.1039/d3dt01678a.

Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria

Alicia Marco  1 , Gloria Vigueras  1 , Natalia Busto  2   3 , Natalia Cutillas  1 , Delia Bautista  4 , José Ruiz  1
Affiliations

Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria

Alicia Marco et al. Dalton Trans. .

Abstract

New valproate Ir(III) and Rh(III) half-sandwich conjugates containing a C,N-phenylbenzimidazole chelated ligand have been synthesized and characterized. The valproic acid conjugation to organometallic fragments seems to switch on the antibacterial activity of the complexes towards Enterococcus faecium and Staphylococcus aureus Gram-positive bacteria.

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