Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep 6;29(50):e202301360.
doi: 10.1002/chem.202301360. Epub 2023 Aug 8.

Experimental and Computational Studies on RuII -Catalyzed C7-Allylation of Indolines with Allyl Bromide

Shiv Shankar Gupta  1   2 , Shivangi Gupta  3 , Manisha  1   2 , Puneet Gupta  3 , Upendra Sharma  1   2
Affiliations

Experimental and Computational Studies on RuII -Catalyzed C7-Allylation of Indolines with Allyl Bromide

Shiv Shankar Gupta et al. Chemistry. .

Abstract

The selective C7-allylation of indolines with allyl bromide under ruthenium catalysis has been revealed here. Under established reaction conditions, C7-allylation of various indolines, including drug compounds, was accomplished with good selectivity and yields. Based on combined experimental and density functional theory (DFT) studies, the olefin insertion route was energetically favorable among four possible pathways. Experimental and DFT studies further revealed that the C-H activation is a reversible rate-limiting step.

Keywords: C−H Activation; allyl bromide; allylation; indoline; ruthenium.

PubMed Disclaimer

References

    1. None
    1. R. Hili, A. K. Yudin, Nat. Chem. Biol. 2006, 2, 284-287;
    1. S. S. Gupta, S. Kumari, I. Kumar, U. Sharma, Chem. Heterocycl. Compd. 2020, 56, 433-444.
    1. None
    1. T. W. Lyons, M. S. Sanford, Chem. Rev. 2010, 110, 1147-1169;

LinkOut - more resources