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Case Reports
. 2023 Nov;67(11):e0027223.
doi: 10.1128/aac.00272-23. Epub 2023 Jun 26.

Development of Meropenem Resistance in a Multidrug-Resistant Campylobacter coli Strain Causing Recurrent Bacteremia in a Hematological Malignancy Patient

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Case Reports

Development of Meropenem Resistance in a Multidrug-Resistant Campylobacter coli Strain Causing Recurrent Bacteremia in a Hematological Malignancy Patient

María Bonilla-Moreno et al. Antimicrob Agents Chemother. 2023 Nov.

Abstract

Campylobacter bacteremia is an uncommon disease that mainly occurs in immunocompromised patients and is associated with antibiotic resistance, particularly in Campylobacter coli. We report a patient with persistent blood infection because of a multidrug-resistant (MDR) C. coli strain over a 3-month period. Through this period monotherapy with meropenem was associated with the development of resistance to it. Improving immunity status and a combined therapy for intestinal decolonization were useful to control persistent C. coli infection in this patient.

Keywords: Campylobacter coli; bloodstream infection; bloodstream infections; hematological patient; meropenem; multidrug resistance; multidrug resistant; whole-genome sequencing (WGS).

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIG 1
FIG 1
Timeline of the treatment, cultures and biomarkers of the patient during hospital stay. A. Line shows the evolution of the C reactive protein (dots) and procalcitonin (squares). B. Variation of neutrophils levels over the same period of time. Treatment received is shown in boxes on the upper side. IPM (imipenem, 500mg/6h); MEM (meropenem, 1g/8h); TZP (piperacillin-tazobactam, 4g/500mg/6h); FOF (fosfomycin, 3g/48 hours); GEN (gentamicin, 560 mg/day); CST (colistin, 2M/6h). Below treatment, frequency of blood and stool cultures is shown. • Positive blood cultures; × Negative blood cultures; ▴ Positive stool cultures. Time to positivity (TTP) of blood cultures (hours) is indicated below each positive result.

Comment in

References

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