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. 2023 Dec;261(12):3541-3547.
doi: 10.1007/s00417-023-06151-9. Epub 2023 Jun 26.

Clinical outcomes of vacuum-dehydrated amniotic membrane (Omnigen) mounted on contact lens (Omnilenz) in eyes with acute chemical eye injuries

Nancy M Lotfy  1 , Salah Al Rashidi  2 , Sherein M Hagras  3
Affiliations

Clinical outcomes of vacuum-dehydrated amniotic membrane (Omnigen) mounted on contact lens (Omnilenz) in eyes with acute chemical eye injuries

Nancy M Lotfy et al. Graefes Arch Clin Exp Ophthalmol. 2023 Dec.

Abstract

Background: Omnigen is a vacuum-dehydrated amniotic membrane transplant. It can be delivered to the eye pre-mounted on a special bandage contact lens (Omnilenz) that enables its application without the need for sutures or glue; the aim of this study is to evaluate the short-term clinical outcomes of Omnilenz-Omnigen complex in eyes with acute chemical injury (CEI).

Methods: A prospective interventional study included patients with different grades of acute CEI attending the casualty between July 2021 and November 2022. All patients received first aid measures followed by the application of Omnilenz-Omnigen within the first 2 days. Patients were followed up for at least 1 month. Primary outcomes include epithelial defect and limbal ischemia. Secondary outcomes include best-corrected visual acuity (BCVA) and tolerability.

Results: The study included 23 eyes of 21 patients with acute CEI mostly due to alcohol (34.8%). After the 1st application, the size of the epithelial defect showed a statistically significant reduction (p = 0.016) with improvement in BCVA (p < 0.001). Restoration of the limbal vascularity was obtained in 56.5% of the eyes. Repeated application of Omnilenz was required in 5 eyes (21.7%). The size of the epithelial defect was reduced after the second application (p = 0.504) with improved BCVA (p = 0.185). After 1st month, complete epithelial healing was achieved in all the eyes. Mild limbal ischemia persists in 3 (13%) of the eyes. Final BCVA showed statistically significant improvement (p < 0.001). None of the patients develops any serious complications.

Conclusion: Omnilenz proved to be easy to apply and well tolerated by patients, with promising clinical outcomes.

Keywords: Amniotic membrane; Chemical eye injury; Epithelial defect; Limbal ischemia; Omnilenz.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
A 31-year-old male patient after alkali corrosive. A At presentation. B 1 week after Omnilenz application
Fig. 2
Fig. 2
A 35-year-old male patient after acidic corrosive. A At presentation. B 1 week after Omnilenz application
Fig. 3
Fig. 3
A 43-year-old female patient after alkali corrosive. A At presentation. B 1 week after Omnilenz application
Fig. 4
Fig. 4
A 28-year-old female patient after alcohol. A At presentation. B 1 week after Omnilenz application
See this image and copyright information in PMC

References

    1. Quesada JM, Lloves JM, Delgado DV. Ocular chemical burns in the workplace: epidemiological characteristics. Burns. 2020;46(5):1212–1218. doi: 10.1016/j.burns.2019.11.007. - DOI - PubMed
    1. Lusk PG. Chemical eye injuries in the workplace. Prevention and management. AAOHN J. 1999;47:80–89. doi: 10.1177/216507999904700207. - DOI - PubMed
    1. Uçakhan OO, Köklü G, Firat E. Non preserved human amniotic membrane transplantation in acute and chronic chemical eye injuries. Cornea. 2002;21(2):169–172. doi: 10.1097/00003226-200203000-00008. - DOI - PubMed
    1. Eslani M, Baradaran-Rafii A, Cheung AY, et al. Amniotic membrane transplantation in acute severe ocular chemical injury: a randomized clinical trial. Am J Ophthalmol. 2019;199:209–215. doi: 10.1016/j.ajo.2018.11.001. - DOI - PubMed
    1. Suri K, Kosker M, Raber IM, et al. Sutureless amniotic membrane ProKera for ocular surface disorders: short-term results. Eye Contact Lens. 2013;39(5):341–347. doi: 10.1097/ICL.0b013e3182a2f8fa. - DOI - PubMed