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. 2023 Sep;77(4):964-971.
doi: 10.1007/s11418-023-01725-7. Epub 2023 Jun 26.

New nitric oxide production inhibitors from Syzygium bullockii

Bui Huu Tai  1   2 , Bui Hai Ninh  2   3 , Pham Hai Yen  1 , Duong Thi Dung  1 , Nguyen Huy Hoang  1 , Nguyen Xuan Nhiem  1 , Nguyen Van Tuyen  3 , Le Tuan Anh  4 , Phan Van Kiem  5   6
Affiliations

New nitric oxide production inhibitors from Syzygium bullockii

Bui Huu Tai et al. J Nat Med. 2023 Sep.

Abstract

Three undescribed triterpene glycosides syzybullosides A-C (1-3) along with fourteen known compounds were isolated from the leaves of Syzygium bullockii (Hance) Merr.& L.M. Perry, including six triterpene glycosides (1-6), four phenolics (7-9, 17), four megastigmanes (10-13), and three flavonoids (14-16). The structures of 1-17 were elucidated by extensive spectroscopic analysis, including IR, HR-ESI-MS, 1D and 2D NMR spectra. Compounds 1-10 and 12-17 inhibited nitric oxide (NO) production in lipopolysaccharide activated RAW264.7 cells with IC50 values ranging from 1.30 to 13.70 µM, lower than that of the positive control compound, L-NMMA (IC50 = 33.8 µM).

Keywords: Myrtaceae; Nitric oxide inhibitor; Syzybulloside; Syzygium bullockii; Triterpene glycoside.

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