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. 2023 Apr;25(2):160-172.
doi: 10.1002/epd2.20003. Epub 2023 May 4.

WISC-IV intellectual profiles in Italian children with self-limited epilepsy with centrotemporal spikes

Martina Paola Zanaboni  1 , Ludovica Pasca  1   2 , Stefania Maria Bova  3 , Matteo Alessio Chiappedi  4 , Melissa Filippini  5 , Lucio Giordano  6 , Serena Grumi  1 , Serena Micheletti  6 , Francesca F Operto  7 , Dario Pruna  8 , Francesca Ragona  9 , Federico Raviglione  10 , Martina Totaro  1   2 , Costanza Varesio  1   2 , Aglaia Vignoli  11 , Valentina De Giorgis  1   2 ; EpilEpsyIt study group
Affiliations

WISC-IV intellectual profiles in Italian children with self-limited epilepsy with centrotemporal spikes

Martina Paola Zanaboni et al. Epileptic Disord. 2023 Apr.

Abstract

Objective: This study aimed to describe the intellectual profile based on the Wechsler Intelligence Scale for Children 4th edition (WISC-IV) in children with self-limited epilepsy with centrotemporal spikes (SeLECTS), with an attempt to define possible predictive epilepsy-related variables of cognitive performance.

Methods: The WISC-IV was assessed in 161 children with SeLECTS and their cognitive profiles were compared to a matched sample of healthy control children.

Results: Children with SeLECTS performed within normal range across all indices, demonstrating particular strength based on the Perceptual Reasoning Index. Compared to healthy control children, we observed a significant difference in performance based on the Full Scale Intelligence Quotient, Verbal Comprehension Index and Processing Speed Index. Regarding epilepsy-related variables, earlier onset of epilepsy, use of anti-seizure medications, the presence of neurodevelopmental disorders, a higher frequency of seizures, and a longer treatment duration were associated with an overall lower level of performance.

Significance: Children with SeLECTS performed within the average range for cognitive assessment based on the WISC-IV, demonstrating that children had normal levels of global intelligence. However, compared to healthy control children, children with SeLECTS showed a slightly lower level of performance. Reasoning skills represented the relative strengths in children with SeLECTS. Predictors of intellectual performance in patients with SeLECTS include epilepsy-related variables and neurodevelopmental comorbidities.

Keywords: SeLECTS; WISC-IV; epilepsy; intelligence; self-limited epilepsy with centrotemporal spikes.

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References

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