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. 2020 Aug 8;2(1):9-25.
doi: 10.1515/almed-2020-0034. eCollection 2021 Mar.

Big data and reference intervals: rationale, current practices, harmonization and standardization prerequisites and future perspectives of indirect determination of reference intervals using routine data

[Article in English, Spanish]
Luisa Martinez-Sanchez  1   2   3 , Fernando Marques-Garcia  4 , Yesim Ozarda  5 , Albert Blanco  1 , Nannette Brouwer  6 , Francesca Canalias  7 , Christa Cobbaert  2 , Marc Thelen  8   9 , Wendy den Elzen  2
Affiliations

Big data and reference intervals: rationale, current practices, harmonization and standardization prerequisites and future perspectives of indirect determination of reference intervals using routine data

[Article in English, Spanish]
Luisa Martinez-Sanchez et al. Adv Lab Med. .

Abstract

Reference intervals are commonly used as a decision-making tool. In this review, we provide an overview on "big data" and reference intervals, describing the rationale, current practices including statistical methods, essential prerequisites concerning data quality, including harmonization and standardization, and future perspectives of the indirect determination of reference intervals using routine laboratory data.

Keywords: big data; indirect methods; reference intervals.

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Conflict of interest statement

Competing interests: Authors state no conflict of interest.

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