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Review
. 2023 Jun 8:17:1209378.
doi: 10.3389/fnins.2023.1209378. eCollection 2023.

Characterization of diffusion magnetic resonance imaging revealing relationships between white matter disconnection and behavioral disturbances in mild cognitive impairment: a systematic review

Yu Zhou  1 , Lan Wei  2 , Song Gao  3 , Jun Wang  4 , Zhigang Hu  1
Affiliations
Review

Characterization of diffusion magnetic resonance imaging revealing relationships between white matter disconnection and behavioral disturbances in mild cognitive impairment: a systematic review

Yu Zhou et al. Front Neurosci. .

Abstract

White matter disconnection is the primary cause of cognition and affection abnormality in mild cognitive impairment (MCI). Adequate understanding of behavioral disturbances, such as cognition and affection abnormality in MCI, can help to intervene and slow down the progression of Alzheimer's disease (AD) promptly. Diffusion MRI is a non-invasive and effective technique for studying white matter microstructure. This review searched the relevant papers published from 2010 to 2022. Sixty-nine studies using diffusion MRI for white matter disconnections associated with behavioral disturbances in MCI were screened. Fibers connected to the hippocampus and temporal lobe were associated with cognition decline in MCI. Fibers connected to the thalamus were associated with both cognition and affection abnormality. This review summarized the correspondence between white matter disconnections and behavioral disturbances such as cognition and affection, which provides a theoretical basis for the future diagnosis and treatment of AD.

Keywords: affection; cognition; diffusion MRI; mild cognitive impairment; white matter disconnection.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The progression of Alzheimer’s disease for each phase.
FIGURE 2
FIGURE 2
An overview of the advanced diffusion magnetic resonance imaging (MRI) techniques examined in this article. DWI, diffusion weighted imaging; D, diffusion; ADC, apparent diffusion coefficient; eADC, exponential ADC; DTI, diffusion tensor imaging; FA, fractional anisotropy; DA, axial diffusivity; DR, radial diffusivity; MD, mean diffusivity; DSI, diffusion spectrum imaging; HARDI, high angular diffusion magnetic imaging; DKI, diffusion kurtosis imaging; MK, mean kurtosis; AK, axial kurtosis; RK, radial kurtosis; NODDI, neurite orientation dispersion and density imaging; ODI, orientation dispersion index; ICVF, intracellular volume fraction; ISO, isotropic volume fraction.
FIGURE 3
FIGURE 3
A modified preferred reporting items for systematic reviews and meta-analyses (PRISMA) flow diagram through the selection study.
See this image and copyright information in PMC

References

    1. Abivardi A., Bach D. R. (2017). Deconstructing white matter connectivity of human amygdala nuclei with thalamus and cortex subdivisions in vivo. Hum. Brain Mapp. 38 3927–3940. 10.1002/hbm.23639 - DOI - PMC - PubMed
    1. Agosta F., Pievani M., Sala S., Geroldi C., Galluzzi S., Frisoni G. B., et al. (2011). White matter damage in Alzheimer disease and its relationship to gray matter atrophy. Radiology 258 853–863. - PubMed
    1. Ahmed S., Arnold R., Thompson S. A., Graham K. S., Hodges J. R. (2008). Naming of objects, faces and buildings in mild cognitive impairment. Cortex 44 746–752. 10.1016/j.cortex.2007.02.002 - DOI - PubMed
    1. Alexander A. L., Lee J. E., Lazar M., Field A. S. (2007). Diffusion tensor imaging of the brain. Neurotherapeutics 4 316–329. - PMC - PubMed
    1. Allen J. W., Yazdani M., Kang J., Magnussen M. J., Qiu D., Hu W. (2019). Patients with mild cognitive impairment may be stratified by advanced diffusion metrics and neurocognitive testing. J. Neuroimaging 29 79–84. 10.1111/jon.12588 - DOI - PubMed

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