Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Mar;7(1):1-5.
doi: 10.5430/crim.v7n1p1. Epub 2019 Dec 12.

Improvement of pulmonary sarcoidosis following sleeve gastrectomy

Natalie E Hassell  1 , Ewa Grzeszczak  2 , Ryan C Adams  3 , Wonder P Drake  4
Affiliations

Improvement of pulmonary sarcoidosis following sleeve gastrectomy

Natalie E Hassell et al. Case Rep Intern Med. 2020 Mar.

Abstract

Pulmonary sarcoidosis is unlikely to resolve if it persists for greater than five years. A growing body of literature supports the involvement of the microbiome in sarcoidosis and a role for sex hormones in pulmonary fibrosis. Additionally, obesity is a risk factor for the development of sarcoidosis. Bariatric surgery is an effective treatment for obesity and can lead to microbial and endocrine changes. Here, we report the clinical improvement of longstanding pulmonary sarcoidosis following sleeve gastrectomy.

Keywords: Bariatric surgery; Estrogen; Microbiome; Obesity; Sarcoidosis.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST DISCLOSURE The authors have declared no conflicts of interest.

Figures

Figure 1.
Figure 1.
CT representation of pulmonary sarcoidosis one year prior to sleeve gastrectomy showing ground glass opacities in the apex (A) and improvement seven months following sleeve gastrectomy (B).
Figure 2.
Figure 2.
CT representation of pulmonary sarcoidosis one year prior to sleeve gastrectomy showing a ground glass nodule in the right lower lobe (A) and improvement seven months following sleeve gastrectomy (B).
See this image and copyright information in PMC

References

    1. Valeyre D, Prasse A, Nunes H, et al. Sarcoidosis. Lancet. 2014; 383(9923): 1155–67. 10.1016/S0140-6736(13)60680-7 - DOI - PubMed
    1. Cozier YC, Coogan PF, Govender P, et al. Obesity and weight gain in relation to incidence of sarcoidosis in US black women: data from the Black Women’s Health Study. Chest. 2015; 147(4): 1086–93. 10.1378/chest.14-1099 - DOI - PMC - PubMed
    1. Dumas O, Boggs KM, Cozier YC, et al. Prospective study of body mass index and risk of sarcoidosis in US women. Eur Respir J. 2017;50(4). 10.1183/13993003.01397-2017 - DOI - PMC - PubMed
    1. Ungprasert P, Crowson CS, Matteson EL. Smoking, obesity and risk of sarcoidosis: A population-based nested case-control study. Respir Med. 2016; 120: 87–90. 10.1016/j.rmed.2016.10.003 - DOI - PMC - PubMed
    1. Cozier YC, Govender P, Berman JS. Obesity and sarcoidosis: consequence or contributor? Curr Opin Pulm Med. 2018; 24(5): 487–94. 10.1097/MCP.0000000000000503 - DOI - PubMed

LinkOut - more resources