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Review
. 2020 Nov 2;1(4):20200083.
doi: 10.1515/almed-2020-0083. eCollection 2020 Dec.

SARS-CoV-2: a new threat

[Article in English, Spanish, Spanish]
Cristina A López Rodríguez  1 , Marc Boigues Pons  1 , Bibiana Quirant Sánchez  1 , Aina Teniente Serra  1 , Joan Climent Martí  1 , Eva Ma Martínez Cáceres  1
Affiliations
Review

SARS-CoV-2: a new threat

[Article in English, Spanish, Spanish]
Cristina A López Rodríguez et al. Adv Lab Med. .

Abstract

Background: The pandemic caused by the emergence of the new SARS-CoV-2 virus worldwide has had a major impact at all levels and has forced in-depth research into its behavior, pathogenicity and treatment.

Content: This review provides an overview of various aspects of the virus and the immune response it triggers, as well as a description of the different diagnostic and therapeutic approaches adopted.

Summary: SARS-COV-2 is a RNA virus with some peculiarities that make it different from its predecessors SARS-CoV and MERS. Given its structural characteristics and pathogenesis, it can cause different clinical manifestations as the disease progresses. The immune system has been proven to play a major role in the response to this virus and, therefore, the study of antibodies and lymphocyte populations during the different stages of the disease is crucial.

Outlook: The knowledge of the effect of the virus and the immune response is crucial for the development of good quality vaccines, therapies and diagnostic techniques, which are essential for the control and eradication of the disease.

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Conflict of interest statement

Competing interests: Authors state no conflict of interest.

Figures

Figure 1:
Figure 1:
Structure of SARS CoV-2. Adapted from Jin y et al. [3].
Figure 2:
Figure 2:
Kinetics of ARN and anti SARS-CoV-2 IgG, IgA and IgM antibodies across the different clinical stages of COVID19.
See this image and copyright information in PMC

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