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. 2023 Apr 29;8(7):1473-1475.
doi: 10.1016/j.ekir.2023.04.026. Online ahead of print.

Humoral and T cell Responses to SARS-CoV-2 Vaccine Booster and Anti-SARS-CoV-2 Monoclonal Antibodies in Patients With End-Stage Kidney Disease

Gianluigi Zaza  1 , Giovanni Stallone  1 , Simona Granata  1 , Micaela Gentile  2 , Maddalena Panico  1 , Sofia Bin  2   3   4 , Lin Wang  5 , Christiane Rollenhagen  6 , Jonathan S Maltzman  6   7 , Paolo Cravedi  2
Affiliations

Humoral and T cell Responses to SARS-CoV-2 Vaccine Booster and Anti-SARS-CoV-2 Monoclonal Antibodies in Patients With End-Stage Kidney Disease

Gianluigi Zaza et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
(a) Humoral and Cell-mediated immunity before and after booster vaccination, breakthrough infection, or anti-SARS-CoV-2 monoclonal antibodies in kidney transplant recipients and in dialysis patients. Anti-RBD IgG concentrations were measured from serum samples using a Luminex based assay.S1 The dashed horizontal line indicates the cutoff used to determine a positive antibody level on the basis of mean plus 3 × SD of pre-COVID sera samples. (b) Cellular reactivity was assessed using frozen peripheral blood mononuclear cells by interferon gamma-ELISpot assay after stimulation with SARS-CoV-2 RBD. IFNγ-producing cell clones were quantified by SFUs per 1 × 106 cells after background subtraction. Connecting lines between the time points indicate matched serum of peripheral blood mononuclear cells samples. The “pre-” time-point for patients with breakthrough infection is at 1 to 3 months after infection. One asterisk denotes P < 0.05, 2 asterisks denote P < 0.01, 3 asterisks denote P < 0.001, and 4 asterisks denote P < 0.0001. HD, hemodialysis; IFNg, interferon gamma; KTx, kidney transplant; MFI, mean fluorescence intensity; RBD, recombinant binding domain; SFU, spot-forming units.
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References

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