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. 2023 Jun 21;11(7):e01183.
doi: 10.1002/rcr2.1183. eCollection 2023 Jul.

Diffuse pulmonary meningotheliomatosis

Anthony Nadrous  1 , Sushilkumar Sonavane  2 , Andras Khoor  3 , Alejandra Yu-Lee Mateus  1 , Augustine Lee  1
Affiliations

Diffuse pulmonary meningotheliomatosis

Anthony Nadrous et al. Respirol Case Rep. .

Abstract

Diffuse pulmonary meningotheliomatosis (DPM) is an ultra-rare pulmonary disease characterized by innumerable bilateral minute meningothelial-like nodules, sometimes presenting a characteristic 'cheerio-sign' on imaging. Most patients with DPM are asymptomatic and experience no disease progression. Although little is known about its nature, DPM may be associated with pulmonary malignancies, mostly lung adenocarcinoma.

Keywords: chest computed tomography; pulmonary meningotheliomatosis; pulmonary nodule.

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Conflict of interest statement

None declared.

Figures

FIGURE 1
FIGURE 1
(A) Computed tomography (CT) of the chest in coronal view showing numerous, randomly distributed, bilateral, solid and ground glass micronodules of 2–4 mm. (B) CT of the chest in axial view showing several nodules exhibiting the characteristic ‘cheerio‐sign’ marked by central lucency (yellow arrows). (C) A thoracoscopic wedge biopsy showing multiple (3) perivenular nodules (haematoxylin & eosin, original magnification ×20). (D) High magnification of DPM biopsy revealing nests of bland cells containing a moderate amount of cytoplasm, round to oval nuclei, and finely granular chromatin (haematoxylin & eosin, original magnification ×400).
See this image and copyright information in PMC

References

    1. Mizutani E, Tsuta K, Maeshima AM, Asamura H, Matsuno Y. Minute pulmonary meningothelial‐like nodules: clinicopathologic analysis of 121 patients. Hum Pathol. 2009;40(5):678–82. [cited 2009 Jan 14]. 10.1016/j.humpath.2008.08.018 - DOI - PubMed
    1. Pelosi G, Maffini F, Decarli N, Viale G. Progesterone receptor immunoreactivity in minute meningothelioid nodules of the lung. Virchows Arch. 2002;440(5):543–6. [cited 2002 Jan 22]. 10.1007/s00428-001-0580-y - DOI - PubMed

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