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. 2024 Jan-Feb;7(1):101-102.
doi: 10.1016/j.ogla.2023.06.010. Epub 2023 Jun 25.

Lowe Oculocerebrorenal Syndrome Comparison of Anterior Segment Anatomy in Eyes with and without Glaucoma

Dhruv M Shah  1 , Libby Wei  1 , He Eun Forbes  1 , Euna Cho  1 , Trisha Miglani  1 , Isabelle Dortonne  2 , Monica M Manrique  2 , Camilo Martinez  2 , William P Madigan  2 , Mohamad S Jaafar  2 , Moran R Levin  1 , Janet L Alexander  3
Affiliations

Lowe Oculocerebrorenal Syndrome Comparison of Anterior Segment Anatomy in Eyes with and without Glaucoma

Dhruv M Shah et al. Ophthalmol Glaucoma. 2024 Jan-Feb.

Abstract

Ultrasound biomicroscopy comparison of two infants with Lowe oculocerebrorenal syndrome, one with glaucoma and one without, found differences in corneal curvature, iris thickness, trabecular-iris angle, and lens morphology are potential glaucoma-associated features.

Keywords: Anterior segment anatomy; Congenital cataract; Lowe syndrome; Oculocerebrorenal syndrome of Lowe; Pediatric glaucoma.

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Figures

Figure 1.
Figure 1.
Pre-lensectomy axial ultrasound biomicroscopy images of anterior segment in eyes with OCRL who developed glaucoma in the right (A) and left (B) eye, and age-matched eyes with OCRL who did not develop glaucoma in the right (D) and left (E) eye. White arrow demonstrates iris strands in A, B, and E. Processed ultrasound biomicroscopy image (using image merging of the right and left eye, edge detection, artifact removal, image smoothing, and color overlay functions) to compare (C) eyes with glaucoma (red) and (F) eyes without glaucoma (blue), in the setting of OCRL. Key differences include 1) Rounded rather than pointed trabecular-iris angle in glaucoma eyes, 2) Increased iris stranding in glaucoma eyes, 3) Thinner lens with irregular capsular boundaries in glaucoma eyes, and 4) Tapered iris in glaucoma eyes.
See this image and copyright information in PMC

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