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. 2023 Jul 13;59(57):8838-8841.
doi: 10.1039/d3cc02526h.

A DNA framework-based dual signal amplification biosensor for portable detection of SARS-CoV-2 and its mutations

Yanzhi Dou  1 , ZiYue Huang  2 , Tie Li  1 , Nokuzola Maboyi  3 , Xianting Ding  3 , Shiping Song  4   2 , Jing Su  3
Affiliations

A DNA framework-based dual signal amplification biosensor for portable detection of SARS-CoV-2 and its mutations

Yanzhi Dou et al. Chem Commun (Camb). .

Abstract

We developed a rapid and accurate biosensor to detect SARS-CoV-2 and distinguish its mutations. Benefitting from a DNA framework-modified ordered interface and a dual signal amplification strategy, our biosensor could detect SARS-CoV-2 with a detection limit down to 10 fM. It performed well on pseudo virus and SARS-CoV-2 RNA standard materials, revealing the potential application in disease diagnosis and spread, in combination with a home-made smartphone.

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