Antisynthetase Syndrome With Paraneoplastic Antibodies

Abstract

Antisynthetase syndrome (ASyS) is an uncommon systemic autoimmune disorder characterized by the presence of autoantibodies targeting aminoacyl-transfer RNA (tRNA) synthetase. The syndrome displays a diverse range of clinical manifestations affecting multiple organs, thereby posing a diagnostic challenge. In this report, we present an unusual case of a patient diagnosed with ASyS, displaying positive anti-PL-12 antibodies along with paraneoplastic antibodies. To the best of our knowledge, this is the first documented case in the existing literature describing ASyS with the presence of anti-PL-12 antibodies and concomitant paraneoplastic antibodies in the context of ductal carcinoma in situ.

Keywords: antisynthetase syndrome; autoimmune disease; ductal carcinoma in-situ; interstitial lung disease; paraneoplastic syndrome.

Figure 1. Facial erythematous rash with scaling.

Figure 2. The patient’s right hand with bluish discoloration of fingers, hyperkeratosis, and scaling of the radial aspect of the second finger.

Figure 3. CT chest demonstrating interstitial lung disease which appears slightly worsened with possible developing honeycombing at the bases, superimposed ground glass opacities within the lung bases, right middle lobe, and lingula.