Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jun 1;13(6):605.
doi: 10.3390/bios13060605.

Application of Shear Horizontal Surface Acoustic Wave (SH-SAW) Immunosensor in Point-of-Care Diagnosis

Chia-Hsuan Cheng  1   2 , Hiromi Yatsuda  1   2 , Mikihiro Goto  3 , Jun Kondoh  1 , Szu-Heng Liu  2 , Robert Y L Wang  4   5   6
Affiliations
Review

Application of Shear Horizontal Surface Acoustic Wave (SH-SAW) Immunosensor in Point-of-Care Diagnosis

Chia-Hsuan Cheng et al. Biosensors (Basel). .

Abstract

Point-of-care testing (POCT), also known as on-site or near-patient testing, has been exploding in the last 20 years. A favorable POCT device requires minimal sample handling (e.g., finger-prick samples, but plasma for analysis), minimal sample volume (e.g., one drop of blood), and very fast results. Shear horizontal surface acoustic wave (SH-SAW) biosensors have attracted a lot of attention as one of the effective solutions to complete whole blood measurements in less than 3 min, while providing a low-cost and small-sized device. This review provides an overview of the SH-SAW biosensor system that has been successfully commercialized for medical use. Three unique features of the system are a disposable test cartridge with an SH-SAW sensor chip, a mass-produced bio-coating, and a palm-sized reader. This paper first discusses the characteristics and performance of the SH-SAW sensor system. Subsequently, the method of cross-linking biomaterials and the analysis of SH-SAW real-time signals are investigated, and the detection range and detection limit are presented.

Keywords: C-reactive protein; POCT; SAW; SH-SAW; apolipoprotein; lipoprotein; point-of-care testing; simulation; surface acoustic wave; whole blood measurement.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
SH-SAW biosensor chip with POCT platform.
Figure 2
Figure 2
Phase change due to SH-SAW velocity change.
Figure 3
Figure 3
The model structures of simulation program. (a) the substrate layer (I) is 36Y-90X quartz, the metal layer (II) is gold, the additional material layer (III) is the protein layer and the liquid layer (IV) is water or a buffer; (b) The substrate layer (I) is 36Y-90X quartz, the metal layer (II) is gold and the liquid layer (III) is a glycerol-water mixture.
Figure 4
Figure 4
False grating area between the FEUDT and the sensing area.
Figure 5
Figure 5
Signal analysis from SH-SAW.
Figure 6
Figure 6
Multiple step measurement of CRP biosensor.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Piovarci I., Melikishvili S., Tatarko M., Hianik T., Thompson M. Detection of Sub-Nanomolar Concentration of Trypsin by Thickness-Shear Mode Acoustic Biosensor and Spectrophotometry. Biosensors. 2021;11:117. doi: 10.3390/bios11040117. - DOI - PMC - PubMed
    1. Liu J., Chen D., Wang P., Song G., Zhang X., Li Z., Wang Y., Wang J., Yang J. A microfabricated thickness shear mode electroacoustic resonator for the label-free detection of cardiac troponin in serum. Talanta. 2020;215:120890. doi: 10.1016/j.talanta.2020.120890. - DOI - PubMed
    1. Wu H., Zhao G., Zu H., Wang J.H., Wang Q.M. Real-Time Monitoring of Platelet Activation Using Quartz Thickness-Shear Mode Resonator Sensors. Biophys. J. 2016;110:669–679. doi: 10.1016/j.bpj.2015.11.3511. - DOI - PMC - PubMed
    1. Dahint R., Bender F., Morhard F. Operation of acoustic plate mode immunosensors in complex biological media. Anal. Chem. 1999;71:3150–3156. doi: 10.1021/ac990119u. - DOI - PubMed
    1. Huang Y., Das P.K., Bhethanabotla V.R. Surface acoustic waves in biosensing applications. Sens. Actuators Rep. 2021;3:100041. doi: 10.1016/j.snr.2021.100041. - DOI