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Review
. 2023 Jun 14;9(6):667.
doi: 10.3390/jof9060667.

Invasive Fungal Infections Associated with COVID-19

Kyaw M Hlaing  1 , Lea M Monday  1 , Marcio Nucci  2 , Simone A Nouér  2 , Sanjay G Revankar  1
Affiliations
Review

Invasive Fungal Infections Associated with COVID-19

Kyaw M Hlaing et al. J Fungi (Basel). .

Abstract

The COVID-19 pandemic caused >6 million deaths worldwide, often from respiratory failure. Complications frequently occurred in hospitalized patients, particularly in the intensive care unit. Among these, fungal infections were a cause of high morbidity and mortality. Invasive aspergillosis, candidiasis and mucormycosis were the most serious of these infections. Risk factors included alterations in immune defense mechanisms by COVID-19 itself, as well as immunosuppression due to various therapies utilized in severely ill patients. Diagnosis was often challenging due to lack of sensitivity of current testing. Outcomes were generally poor, due to significant co-morbidities and delayed diagnosis, with mortality rates >50% in some studies. High index of clinical suspicion is needed to facilitate early diagnosis and initiation of appropriate antifungal therapy.

Keywords: COVID-19; aspergillosis; candidiasis; mucormycosis.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. World Health Organization (WHO) [(accessed on 31 July 2022)]. Available online: https://covid19.who.int/
    1. Lai C.-C., Yu W.-L. COVID-19 associated with pulmonary aspergillosis: A literature review. J. Microbiol. Immunol. Infect. 2020;54:46–53. doi: 10.1016/j.jmii.2020.09.004. - DOI - PMC - PubMed
    1. Rawson T.M., Moore L.S.P., Zhu N., Ranganathan N., Skolimowska K., Gilchrist M., Satta G., Cooke G., Holmes A.H. Bacterial and Fungal Coinfection in Individuals With Coronavirus: A Rapid Review To Support COVID-19 Antimicrobial Prescribing. Clin. Infect. Dis. 2020;71:2459–2468. doi: 10.1093/cid/ciaa530. - DOI - PMC - PubMed
    1. Chiurlo M., Mastrangelo A., Ripa M., Scarpellini P. Invasive fungal infections in patients with COVID-19: A review on patho-genesis, epidemiology, clinical features, treatment, and outcomes. New Microbiol. 2021;44:71–83. - PubMed
    1. Song G., Liang G., Liu W. Fungal Co-infections Associated with Global COVID-19 Pandemic: A Clinical and Diagnostic Perspective from China. Mycopathologia. 2020;185:599–606. doi: 10.1007/s11046-020-00462-9. - DOI - PMC - PubMed

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