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Review
. 2023 Jun 6;15(6):383.
doi: 10.3390/toxins15060383.

Enniatin B1: Emerging Mycotoxin and Emerging Issues

Beatrice De Felice  1 , Leon J Spicer  2 , Francesca Caloni  1
Affiliations
Review

Enniatin B1: Emerging Mycotoxin and Emerging Issues

Beatrice De Felice et al. Toxins (Basel). .

Abstract

Although over the last 10 years several studies have focused on the emerging mycotoxins known as enniatins (ENNs), there is still a lack of knowledge regarding their toxicological effects and the development of a correct risk assessment. This is especially true for enniatin B1 (ENN B1), considered the younger sister of the widely studied enniatin B (ENN B). ENN B1 has been found in several food commodities and, as with other mycotoxins, presents antibacterial and antifungal properties. On the other hand, ENN B1 has shown cytotoxic activity, impairment of the cell cycle, the induction of oxidative stress, and changes in mitochondrial membrane permeabilization, as well as negative genotoxic and estrogenic effects. Overall, considering the paucity of information available regarding ENN B1, further studies are necessary to perform a risk assessment. This review summarizes information on the biological characteristics and toxicological effects of ENN B1 as well as the future challenges that this mycotoxin could present.

Keywords: biological characteristics; emerging mycotoxins; enniatin B1; toxicological effects.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Enniatin A, A1, B, and B1 structures.
Figure 2
Figure 2
Enniatin B1 (ENN B1): biological characteristics (A) and toxicological effects (B).
See this image and copyright information in PMC

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