EZH2i unlocks PDAC immune surveillance

Affiliations

Comment

Helene Damhofer et al. Nat Cancer. 2023 Jun.

. 2023 Jun;4(6):781-783.

doi: 10.1038/s43018-023-00562-7.

No abstract available

Comment on

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance.
Chibaya L, Murphy KC, DeMarco KD, Gopalan S, Liu H, Parikh CN, Lopez-Diaz Y, Faulkner M, Li J, Morris JP 4th, Ho YJ, Chana SK, Simon J, Luan W, Kulick A, de Stanchina E, Simin K, Zhu LJ, Fazzio TG, Lowe SW, Ruscetti M. Chibaya L, et al. Nat Cancer. 2023 Jun;4(6):872-892. doi: 10.1038/s43018-023-00553-8. Epub 2023 May 4. Nat Cancer. 2023. PMID: 37142692 Free PMC article.

1. Chibaya, L. et al. Nat. Cancer https://doi.org/10.1038/s43018-023-00553-8 (2023). - DOI - PubMed
1. Waldman, A. D., Fritz, J. M. & Lenardo, M. J. Nat. Rev. Immunol. 20, 651–668 (2020). - DOI - PubMed - PMC
1. Bear, A. S., Vonderheide, R. H. & O’Hara, M. H. Cancer Cell 38, 788–802 (2020). - DOI - PubMed - PMC
1. Petroni, G. et al. Cancer Cell 39, 310–345 (2021). - DOI - PubMed
1. Ruscetti, M. et al. Cell 181, 424–441 e421 (2020). - DOI - PubMed - PMC