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Review
. 2023 Jun 15;12(6):1054.
doi: 10.3390/antibiotics12061054.

Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023

Mehmet Kursat Yilmaz  1   2 , Ahmad Abbaszadeh  1 , Saad Tarabichi  1 , Ibrahim Azboy  2 , Javad Parvizi  1
Affiliations
Review

Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023

Mehmet Kursat Yilmaz et al. Antibiotics (Basel). .

Abstract

Periprosthetic joint infection (PJI) is a rare yet devastating complication following total joint arthroplasty (TJA). Early and accurate diagnosis of PJI is paramount in order to maximize the chances of successful treatment. However, we are yet to identify a single "gold standard" test for the diagnosis of PJI. As a result, the diagnosis of PJI is often challenging. Currently, the 2018 ICM definition of PJI is the only validated diagnostic criteria available. This article will review the importance of serum and synovial biomarkers in the diagnosis of PJI. In addition, it will provide a brief overview of the emerging modalities for the identification of infections in this setting.

Keywords: marker; periprosthetic joint infection; serum; synovial fluid.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
2018 İnternational Consensus Meeting criteria for the diagnosis of PJI. CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; LE, leukocyte esterase; PMN, polymorphonuclear; WBC, white blood cell. a: For patients with inconclusive minorcriteria, operative criteria can also be used to fulfill definition for PJI. b: Consider further molecular diagnostics such as next-generation sequencing.
Figure 2
Figure 2
Commonly used serum-plasma and synovial markers for diagnosing PJI.
See this image and copyright information in PMC

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