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Review
. 2023 Jun 15;15(12):3200.
doi: 10.3390/cancers15123200.

Tumorigenesis in Inflammatory Bowel Disease: Microbiota-Environment Interconnections

Irene Mignini  1 , Maria Elena Ainora  1 , Silvino Di Francesco  1 , Linda Galasso  1 , Antonio Gasbarrini  1 , Maria Assunta Zocco  1
Affiliations
Review

Tumorigenesis in Inflammatory Bowel Disease: Microbiota-Environment Interconnections

Irene Mignini et al. Cancers (Basel). .

Abstract

Colo-rectal cancer (CRC) is undoubtedly one of the most severe complications of inflammatory bowel diseases (IBD). While sporadic CRC develops from a typical adenoma-carcinoma sequence, IBD-related CRC follows different and less understood pathways and its pathophysiological mechanisms were not completely elucidated. In contrast to chronic inflammation, which is nowadays a well-recognised drive towards neoplastic transformation in IBD, only recently was gut microbiota demonstrated to interfere with both inflammation processes and immune-mediated anticancer surveillance. Moreover, the role of microbiota appears particularly complex and intriguing when also considering its multifaceted interactions with multiple environmental stimuli, notably chronic pathologies such as diabetes and obesity, lifestyle (diet, smoking) and vitamin intake. In this review, we presented a comprehensive overview on current evidence of the influence of gut microbiota on IBD-related CRC, in particular its mutual interconnections with the environment.

Keywords: colo-rectal cancer; gut microbiota; inflammatory bowel disease; tumorigenesis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Multiple interactions between gut microbiota and environmental factors implicated in IBD-related carcinogenesis.
See this image and copyright information in PMC

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