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. 2023 Jun 20;13(12):2127.
doi: 10.3390/diagnostics13122127.

Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms

Dana Zelnik Yovel  1   2 , Erwin Santo  3 , Majd Khader  2 , Roie Tzadok  2   3 , Nir Bar  2   3 , Asaf Aizic  2   4 , Oren Shibolet  2   3 , Dana Ben-Ami Shor  2   3
Affiliations

Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms

Dana Zelnik Yovel et al. Diagnostics (Basel). .

Abstract

The association between intraductal papillary mucinous neoplasms (IPMNs) and extra-pancreatic malignancies is controversial. This cross-sectional study compared esophagogastroduodenal findings in 340 IPMN patients to those of age- and gender-matched controls without known IPMNs who underwent esophagogastroduodenoscopies (EGDs) for similar clinical reasons. The presence of gastric and esophageal cancer, Barrett's esophagus, neuroendocrine tumors (NETs), gastrointestinal stromal tumors (GISTs), gastric adenomas, and ampullary tumors was assessed. The results showed that 4/340 (1.2%) of the IPMN patients had gastric cancer and 1/340 (0.3%) had esophageal cancer. The matched control group had a similar incidence of gastric cancer (5/340) (1.5%), with no esophageal cancer cases (p > 0.999). The overall incidence of other esophagogastroduodenal conditions did not significantly differ between the IPMN patients and the controls. However, the incidence of gastric cancer in the IPMN patients was higher than expected based on national cancer registry data (standardized incidence ratio of 31.39; p < 0.001; CI 8.38-78.76). In conclusion, IPMN patients have a significantly higher incidence of gastric cancer compared to the general population. However, the incidence of esophagogastroduodenal findings, including gastric and esophageal cancer, is similar between IPMN patients and those who undergo an EGD for similar clinical indications. Further research is needed to determine optimal surveillance strategies for IPMN patients regarding their risk of developing gastric cancer.

Keywords: esophageal cancer; gastric cancer; intraductal papillary mucinous neoplasms (IPMNs).

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Endoscopic, sonographic, radiologic, and histologic imaging of IPMN patients diagnosed with gastric cancer in their first EGD. (a) Case 1; (b) Case 2; (c) Case 3; (d) Case 4.
Figure 1
Figure 1
Endoscopic, sonographic, radiologic, and histologic imaging of IPMN patients diagnosed with gastric cancer in their first EGD. (a) Case 1; (b) Case 2; (c) Case 3; (d) Case 4.
See this image and copyright information in PMC

References

    1. Elta G.H., Enestvedt B.K., Sauer B.G., Lennon A.M. ACG Clinical Guideline: Diagnosis and Management of Pancreatic Cysts. Am. J. Gastroenterol. 2018;113:464–479. doi: 10.1038/ajg.2018.14. - DOI - PubMed
    1. Tada M., Kawabe T., Arizumi M., Togawa O., Matsubara S., Yamamoto N., Nakai Y., Sasahira N., Hirano K., Tsujino T., et al. Pancreatic cancer in patients with pancreatic cystic lesions: A prospective study in 197 patients. Clin. Gastroenterol. Hepatol. 2006;4:1265–1270. doi: 10.1016/j.cgh.2006.07.013. - DOI - PubMed
    1. Oyama H., Tada M., Takagi K., Tateishi K., Hamada T., Nakai Y., Hakuta R., Ijichi H., Ishigaki K., Kanai S., et al. Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms. Gastroenterology. 2020;158:226–237.e5. doi: 10.1053/j.gastro.2019.08.032. - DOI - PubMed
    1. Yoon W.J., Ryu J.K., Lee J.K., Woo S.M., Lee S.H., Park J.K., Kim Y.T., Yoon Y.B. Extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasm of the pancreas: Prevalence, associated factors, and comparison with patients with other pancreatic cystic neoplasms. Ann. Surg. Oncol. 2008;15:3193–3198. doi: 10.1245/s10434-008-0143-4. - DOI - PubMed
    1. Choi M.G., Kim S.W., Han S.S., Jang J.Y., Park Y.H. High incidence of extrapancreatic neoplasms in patients with intraductal papillary mucinous neoplasms. Arch. Surg. 2006;141:51–56; discussion 56. doi: 10.1001/archsurg.141.1.51. - DOI - PubMed

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