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. 2023 May 31;10(6):980.
doi: 10.3390/children10060980.

Multi-Inflammatory Syndrome in Children (MIS-C) in 2023: Is It Time to Forget about It?

Francesco La Torre  1 , Andrea Taddio  2 , Chiara Conti  3 , Marco Cattalini  3
Affiliations

Multi-Inflammatory Syndrome in Children (MIS-C) in 2023: Is It Time to Forget about It?

Francesco La Torre et al. Children (Basel). .

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is defined as a clinically serious condition requiring hospitalization involving fever, multi-system organ dysfunction, and an increase in inflammatory biomarkers. The syndrome was originally described as a post-infectious complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which usually causes COVID-19. During the COVID-19 pandemic, not only did the virus undergo mutations but vaccines against SARS-CoV-2 were also developed. Both these conditions led to a decrease in the incidence of MIS-C. This narrative review summarizes the recent updates for MIS-C, particularly regarding the change in incidence, the link between the SARS-CoV-2 vaccine and MIS-C, and new updates of MIS-C treatments.

Keywords: COVID-19; IVIG; MIS-C; SARS-CoV-2 vaccine; anakinra; children; corticosteroids.

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Conflict of interest statement

The authors declare no conflict of interest.

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